Journal article
The role of glucose in cognition, risk of dementia, and related biomarkers in individuals without type 2 diabetes mellitus or the metabolic syndrome: A systematic review of observational studies
Neuroscience & Biobehavioral Reviews, Vol.135, Art. 104551
2022
Abstract
Background
Excessive blood glucose promotes neuropathological cognitive decline in individuals with type 2 diabetes mellitus and the metabolic syndrome, but no systematic synthesis of the evidence for the same association exists in individuals without these conditions.
Objectives
To systematically review studies exploring the role of glucose on cognition, dementia risk, and related biomarkers in adults without diabetes or metabolic syndrome.
Data sources
We searched databases from inception until July 2021 and manually searched the reference lists of included studies. Risk of bias was assessed using the Joanna Briggs Institute tool.
Results
We found 46 observational studies including approximately 98,216 participants. Substantial heterogeneity in study results precluded drawing definitive conclusion whether blood glucose levels are associated with cognition or dementia risk. Higher blood glucose, however, was associated with greater amyloid burden, brain atrophy, and reduced cortical thickness.
Conclusions and implications
High glucose concentrations in blood may exacerbate dementia-related neuropathology but whether this translates into pathological cognitive decline or elevate dementia risk later in life remains unclear.
Details
- Title
- The role of glucose in cognition, risk of dementia, and related biomarkers in individuals without type 2 diabetes mellitus or the metabolic syndrome: A systematic review of observational studies
- Authors/Creators
- M. Kirvalidze (Author/Creator)A. Hodkinson (Author/Creator)D. Storman (Author/Creator)T.J. Fairchild (Author/Creator)M.M. Bała (Author/Creator)G. Beridze (Author/Creator)A. Zuriaga (Author/Creator)N.I. Brudasca (Author/Creator)S. Brini (Author/Creator)
- Publication Details
- Neuroscience & Biobehavioral Reviews, Vol.135, Art. 104551
- Publisher
- Elsevier
- Identifiers
- 991005543097307891
- Copyright
- © 2022 Elsevier Ltd.
- Murdoch Affiliation
- Centre for Healthy Ageing; Centre for Molecular Medicine and Innovative Therapeutics; Health Futures Institute
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Metrics
61 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.52 Neurodegenerative Diseases
- 1.52.60 Dementia
- Web Of Science research areas
- Behavioral Sciences
- Neurosciences
- ESI research areas
- Neuroscience & Behavior