Journal article
The role of interleukin-17 in immune-mediated inflammatory myopathies and possible therapeutic implications
Neuromuscular Disorders, Vol.24(11), pp.943-952
2014
Abstract
The idiopathic inflammatory myopathies are a heterogeneous group of autoimmune muscle disorders with distinct clinical and pathological features and underlying immunopathogenic mechanisms. Traditionally, CD4+ Th1 cells or CD8+ cytotoxic effector T cells and type I/II interferons have been primarily implicated in the pathogenesis of the inflammatory myopathies. The presence of IL-17A producing cells in the inflamed muscle tissue of myositis patients and the results of in vitro studies suggest that IL-17A and the Th17 pathway may also have a key role in these diseases. The contribution of IL-17A to other chronic inflammatory and autoimmune diseases has been well established and clinical trials of IL-17A inhibitors are now at an advanced stage. However the precise role of IL-17A in the various forms of myositis and the potential for therapeutic targeting is currently unknown and warrants further investigation.
Details
- Title
- The role of interleukin-17 in immune-mediated inflammatory myopathies and possible therapeutic implications
- Authors/Creators
- E.M. Moran (Author/Creator)F.L. Mastaglia (Author/Creator)
- Publication Details
- Neuromuscular Disorders, Vol.24(11), pp.943-952
- Publisher
- Elsevier BV
- Identifiers
- 991005541017307891
- Copyright
- © 2014 Elsevier B.V.
- Murdoch Affiliation
- Institute for Immunology and Infectious Diseases
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.106 Rheumatology
- 1.106.1684 Dermatomyositis
- Web Of Science research areas
- Clinical Neurology
- Neurosciences
- ESI research areas
- Neuroscience & Behavior