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The role of liver progenitor cells during liver regeneration, fibrogenesis and carcinogenesis
Journal article   Peer reviewed

The role of liver progenitor cells during liver regeneration, fibrogenesis and carcinogenesis

J. Köhn-Gaone, J. Gogoi-Tiwari, G.A. Ramm, J.K. Olynyk and J.E.E. Tirnitz-Parker
American Journal of Physiology: Gastrointestinal and Liver Physiology, Vol.310(3), pp.G143-G154
2015
DOI: https://doi.org/10.1152/ajpgi.00215.2015
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Abstract

The growing worldwide challenge of cirrhosis and hepatocellular carcinoma due to increasing prevalence of excessive alcohol consumption, viral hepatitis, obesity, and the metabolic syndrome has sparked interest in stem cell-like liver progenitor cells (LPCs) as potential candidates for cell therapy and tissue engineering, as an alternative approach to whole organ transplantation. However, LPCs always proliferate in chronic liver diseases with a predisposition to cancer; they have been suggested to play major roles in driving fibrosis, disease progression, and may even represent tumor-initiating cells. Hence, a greater understanding of the factors that govern their activation, communication with other hepatic cell types, and bipotential differentiation as opposed to their potential transformation is needed before their therapeutic potential can be harnessed.

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UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

Source: InCites

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42 Record Views
38 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types
Domestic collaboration
Citation topics
1 Clinical & Life Sciences
1.102 Stem Cell Research
1.102.1150 Hepatocyte Growth Factor
Web Of Science research areas
Gastroenterology & Hepatology
Physiology
ESI research areas
Clinical Medicine
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