Journal article
The role of neurotrophins and neurexins genes in the risk of paranoid schizophrenia in Russians and Tatars
Russian Journal of Genetics, Vol.51(7), pp.683-694
2015
Abstract
Schizophrenia affects about 1% of the population. Its etiology is not fully understood. Environmental conditions certainly contribute to the development of schizophrenia, but the determining factor is genetic predisposition: the coefficient of heritability of schizophrenia is about 80%, which is typical for the most highly heritable multifactorial diseases. Polymorphic loci of genes of enzymes and receptors involved in the processes of neuroprotection and neurotrophia play significant role in the development of this disease. In this paper we investigated 48 polymorphic variants of genes of the neurotrophins and neurexins family (BDNF, NTRK2, NTRK3, NGF, NXPH1, and NRXN1) in Russian and Tatar cases and in a control group living in the Republic of Bashkortostan. The results of this study confirm the important role of neurotrophin and neurexin genes in paranoid schizophrenia development.
Details
- Title
- The role of neurotrophins and neurexins genes in the risk of paranoid schizophrenia in Russians and Tatars
- Authors/Creators
- A.E. Gareeva (Author/Creator) - Pacific InstituteT. Traks (Author/Creator) - University of TartuS. Kõks (Author/Creator) - University of TartuE.K. Khusnutdinova (Author/Creator) - Pacific Institute
- Publication Details
- Russian Journal of Genetics, Vol.51(7), pp.683-694
- Publisher
- Pleiades Publishing
- Identifiers
- 991005540271307891
- Copyright
- © 2015 Pleiades Publishing, Inc.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.5 Neuroscience
- 1.5.767 Hippocampal Neurogenesis
- Web Of Science research areas
- Genetics & Heredity
- ESI research areas
- Molecular Biology & Genetics