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Published (Version of Record)CC BY-NC-ND V4.0, Open Access
Journal article
The synthesis, characterisation and in vivo study of a bioceramic for potential tissue regeneration applications
Scientific Reports, Vol.4, Article number 6235
2014
Abstract
Hydroxyapatite (HAP) is a biocompatible ceramic that is currently used in a number of current biomedical applications. Recently, nanometre scale forms of HAP have attracted considerable interest due to their close similarity to the inorganic mineral component of the bone matrix found in humans. In this study ultrafine nanometre scale HAP powders were prepared via a wet precipitation method under the influence of ultrasonic irradiation. The resulting powders were compacted and sintered to form a series of ceramic pellets with a sponge-like structure with varying density and porosity. The crystalline structure, size and morphology of the powders and the porous ceramic pellets were investigated using advanced characterization techniques. The pellets demonstrated good biocompatibility, including mixed cell colonisation and matrix deposition, in vivo following surgical implantation into sheep M. latissimus dorsi.
Details
- Title
- The synthesis, characterisation and in vivo study of a bioceramic for potential tissue regeneration applications
- Authors/Creators
- G.E.J. Poinern (Author/Creator) - Murdoch UniversityR.K. Brundavanam (Author/Creator) - Murdoch UniversityX.T. Le (Author/Creator) - Murdoch UniversityP.K. Nicholls (Author/Creator) - Murdoch UniversityM.A. Cake (Author/Creator) - Murdoch UniversityD. Fawcett (Author/Creator) - Murdoch University
- Publication Details
- Scientific Reports, Vol.4, Article number 6235
- Publisher
- Nature Publishing Group
- Identifiers
- 991005540696107891
- Copyright
- © Poinern et al
- Murdoch Affiliation
- School of Engineering and Information Technology; School of Veterinary and Life Sciences
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 2 Chemistry
- 2.165 Nanofibers, Scaffolds & Fabrication
- 2.165.163 Hydroxyapatite Composites
- Web Of Science research areas
- Engineering, Biomedical
- ESI research areas
- Materials Science