Journal article
The vasa locus in Zebrafish: Multiple RGG boxes from duplications
DNA and Cell Biology, Vol.22(1), pp.47-54
2003
Abstract
Vasa is the most extensively characterized germ cell-specific marker in metazoans. We determined the sequence of the zebrafish vasa locus, which - together with the flanking regions - is 25 kb long. It contains 26 + 1 exons, with an average length of 83 bp. The 5′ end of zebrafish vasa is rich in repeats; it includes a peculiar tandem repeat with three units spanning a total of eight exons, each unit containing several tandemly arranged RNA-binding motifs (RGG boxes). The presence of various, nonmicrosatellite type repeats in vasa seems to be universal among the species studied, and could have functional importance during the evolution of the gene, due to the increase in the number of RGG boxes located in these repeats. Analysis of vasa transcripts in zebrafish identified numerous isoforms resulting from alternative splicing (seven) and polyadenylation (four). Mapping to two radiation hybrid panels strengthened the position of the gene on LG10 of zebrafish.
Details
- Title
- The vasa locus in Zebrafish: Multiple RGG boxes from duplications
- Authors/Creators
- R. Bartfai (Author/Creator) - Temasek Life Sciences LaboratoryL. Orbán (Author/Creator) - Temasek Life Sciences Laboratory
- Publication Details
- DNA and Cell Biology, Vol.22(1), pp.47-54
- Publisher
- Mary Ann Liebert Inc.
- Identifiers
- 991005541966707891
- Copyright
- © 2003 Mary Ann Liebert, Inc.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 3 Agriculture, Environment & Ecology
- 3.2 Marine Biology
- 3.2.1123 Fish Reproductive Biology
- Web Of Science research areas
- Biochemistry & Molecular Biology
- Cell Biology
- Genetics & Heredity
- ESI research areas
- Molecular Biology & Genetics