The water-soluble components of the essential oil of Melaleuca alternifolia (tea tree oil) suppress the production of superoxide by human monocytes, but not neutrophils, activated in vitro

C. Brand; A. Ferrante; R.H. Prager; T.V. Riley; C.F. Carson; J.J. Finlay-Jones; P.H. Hart

doi:10.1007/s000110050746

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The water-soluble components of the essential oil of Melaleuca alternifolia (tea tree oil) suppress the production of superoxide by human monocytes, but not neutrophils, activated in vitro

Journal article

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The water-soluble components of the essential oil of Melaleuca alternifolia (tea tree oil) suppress the production of superoxide by human monocytes, but not neutrophils, activated in vitro

C. Brand, A. Ferrante, R.H. Prager, T.V. Riley, C.F. Carson, J.J. Finlay-Jones and P.H. Hart

Inflammation Research, Vol.50(4), pp.213-219

2001

DOI: https://doi.org/10.1007/s000110050746

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Abstract

Objective: To evaluate the regulatory properties of the essential oil of Melaleuca altermfolia (tea tree oil) on the production of oxygen derived reactive species by human peripheral blood leukocytes activated in vitro. Materials and methods: The ability of tea tree oil to reduce superoxide production by neutrophils and monocytes stimulated with N-formyl-methionyl-leucyl-phenylalanine (fMLP), lipopolysaccharide (LPS) or phorbol 12-myristate 13-acetate (PMA) was examined. Results: The water-soluble fraction of tea tree oil had no significant effect on agonist-stimulated superoxide production by neutrophils, but significantly and dose-dependently suppressed agonist-stimulated superoxide production by monocytes. This suppression was not due to cell death. Chemical analysis identified the water-soluble components to be terpinen-4-ol, α-terpineol and 1,8-cineole. When examined individually, terpinen-4-ol significantly suppressed fMLP- and LPS- but not PMA-stimulated superoxide production; α-terpineol significantly suppressed fMLP-, LPS- and PMA-stimulated superoxide production; 1,8-cineole was without effect. Conclusion: Tea tree oil components suppress the production of superoxide by monocytes, but not neutrophils, suggesting the potential for selective regulation of cell types by these components during inflammation.

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Title: The water-soluble components of the essential oil of Melaleuca alternifolia (tea tree oil) suppress the production of superoxide by human monocytes, but not neutrophils, activated in vitro
Authors/Creators: C. Brand (Author/Creator) - Flinders University
A. Ferrante (Author/Creator) - Women's and Children's Hospital
R.H. Prager (Author/Creator) - Flinders University
T.V. Riley (Author/Creator) - The University of Western Australia
C.F. Carson (Author/Creator) - The University of Western Australia
J.J. Finlay-Jones (Author/Creator) - Flinders University
P.H. Hart (Author/Creator) - Flinders University
Publication Details: Inflammation Research, Vol.50(4), pp.213-219
Publisher: Birkhauser Verlag Basel
Identifiers: 991005545116307891
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 3 Agriculture, Environment & Ecology; 3.16 Phytochemicals; 3.16.314 Essential Oil
Web Of Science research areas: Cell Biology; Immunology
ESI research areas: Immunology