Journal article
The western dietary pattern is prospectively associated with non-alcoholic fatty liver disease in adolescence
The American Journal of Gastroenterology, Vol.108(5), pp.778-785
2013
Abstract
OBJECTIVES:
Poor dietary habits have been implicated in the development of nonalcoholic fatty liver disease (NAFLD); however, little is known about the role of specific dietary patterns in the development of NAFLD. We examined prospective associations between dietary patterns and NAFLD in a population-based cohort of adolescents.
METHODS:
Participants in the Western Australian Pregnancy Cohort (Raine) Study completed a food frequency questionnaire at 14 years and had liver ultrasound at 17 years (n=995). Healthy and Western dietary patterns were identified using factor analysis and all participants received a z-score for these patterns. Prospective associations between the dietary pattern scores and risk of NAFLD were analyzed using multiple logistic regression.
RESULTS:
NAFLD was present in 15.2% of adolescents. A higher Western dietary pattern score at 14 years was associated with a greater risk of NAFLD at 17 years (odds ratio (OR) 1.59; 95% confidence interval (CI) 1.17-2.14; P<0.005), although these associations were no longer significant after adjusting for body mass index at 14 years. However, a healthy dietary pattern at 14 years appeared protective against NAFLD at 17 years in centrally obese adolescents (OR 0.63; 95% CI 0.41-0.96; P=0.033), whereas a Western dietary pattern was associated with an increased risk of NAFLD.
CONCLUSIONS:
A Western dietary pattern at 14 years in a general population sample was associated with an increased risk of NAFLD at 17 years, particularly in obese adolescents. In centrally obese adolescents with NAFLD, a healthy dietary pattern may be protective, whereas a Western dietary pattern may increase the risk.
Details
- Title
- The western dietary pattern is prospectively associated with non-alcoholic fatty liver disease in adolescence
- Authors/Creators
- W.H. Oddy (Author/Creator)C.E. Herbison (Author/Creator)P. Jacoby (Author/Creator)G.L. Ambrosini (Author/Creator)T.A. O'Sullivan (Author/Creator)O.T. Ayonrinde (Author/Creator)J.K. Olynyk (Author/Creator)L.J. Black (Author/Creator)L.J. Beilin (Author/Creator)T.A. Mori (Author/Creator)B.P. Hands (Author/Creator)L.A. Adams (Author/Creator)
- Publication Details
- The American Journal of Gastroenterology, Vol.108(5), pp.778-785
- Publisher
- Nature Publishing Group
- Identifiers
- 991005544740807891
- Copyright
- © 2013 The American College of Gastroenterology
- Murdoch Affiliation
- Institute for Immunology and Infectious Diseases
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.125 Hepatitis
- 1.125.663 NAFLD
- Web Of Science research areas
- Gastroenterology & Hepatology
- ESI research areas
- Clinical Medicine