Journal article
Therapeutic Potential of Thymoquinone and Its Nanoformulations in Pulmonary Injury: A Comprehensive Review
International Journal of Nanomedicine, Vol.16, pp.5117-5131
2021
Abstract
As a crucial organ, the lung is exposed to various harmful agents that may induce inflammation and oxidative stress, which may cause chronic or acute lung injury. Nigella sativa, also known as black seed, has been widely used to treat various diseases and is one of the most extensively researched medicinal plants. Thymoquinone (TQ) is the main component of black seed volatile oil and has been proven to have antioxidant, anti-inflammatory, and antineoplastic properties. The potential therapeutic properties of TQ against various pulmonary disorders have been studied in both in vitro and in vivo studies. Furthermore, the application of nanotechnology may increase drug solubility, cellular absorption, drug release (sustained or control), and drug delivery to lung tissue target sites. As a result, fabricating TQ as nanoparticles (NPs) is a potential therapeutic approach against a variety of lung diseases. In this current review, we summarize recent findings on the efficacy of TQ and its nanotypes in lung disorders caused by immunocompromised conditions such as cancer, diabetes, gastric ulcers, and other neurodegenerative diseases. It is concluded that TQ nanoparticles with anti-inflammatory, antioxidant, antiasthma, and antitumor activity may be safely applied to treat lung disorders. However, more research is required before TQ nanoparticles can be used as pharmaceutical preparations in human studies.
Details
- Title
- Therapeutic Potential of Thymoquinone and Its Nanoformulations in Pulmonary Injury: A Comprehensive Review
- Authors/Creators
- N.A. Al-Gabri (Author/Creator) - Thamar UniversityS.AM. Saghir (Author/Creator)S.A. Al-Hashedi (Author/Creator) - King Faisal UniversityA.H. El-Far (Author/Creator) - Damanhour UniversityA.F. Khafaga (Author/Creator) - Alexandria UniversityA.A. Swelum (Author/Creator)A.S. Al-wajeeh (Author/Creator) - Anti-Doping LaboratoryS.A. Mousa (Author/Creator) - Albany College of Pharmacy and Health SciencesM.E. Abd El-Hack (Author/Creator)M.A.E. Naiel (Author/Creator) - Zagazig UniversityK.A. El-Tarabily (Author/Creator)
- Publication Details
- International Journal of Nanomedicine, Vol.16, pp.5117-5131
- Publisher
- Dove Press
- Identifiers
- 991005541977607891
- Copyright
- © 2021 Al-Gabri et al.
- Murdoch Affiliation
- Harry Butler Institute
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 3 Agriculture, Environment & Ecology
- 3.16 Phytochemicals
- 3.16.2237 Thymoquinone
- Web Of Science research areas
- Nanoscience & Nanotechnology
- Pharmacology & Pharmacy
- ESI research areas
- Pharmacology & Toxicology