Journal article
Therapeutic Potential of miR-494 in Thrombosis and Other Diseases: A Review
Australian Journal of Chemistry, Vol.69(10), pp.1078-1093
2016
Abstract
Functional nucleic acids, such as microRNAs (miRNAs), have been implicated in the pathophysiology of many diseases. The miRNA expression profiles of various cancers including haematological malignancies are well defined, but the role of miRNAs in haemostasis and the regulation of coagulation is poorly understood. We identified that miR-494 is oestrogen responsive and directly targets the anticoagulant protein, Protein S, as a mechanism for acquiring Protein S deficiency under high oestrogenic conditions such as during pregnancy and oral contraceptive use. Furthermore, previous studies have also characterised miR-494 to be involved in many biological processes. This paper reviews the current knowledge in the role of miRNAs in regulating haemostatic proteins and the known biological functions of miR-494, highlighting miR-494 as an emerging therapeutic target, with an overview of the strategy we have employed in identifying functional nucleic acids such as miRNAs that target haemostatic factors and the therapeutic potential of miR-494-directed therapy for the treatment of thrombotic disorders.
Details
- Title
- Therapeutic Potential of miR-494 in Thrombosis and Other Diseases: A Review
- Authors/Creators
- J. Tay (Author/Creator) - Murdoch UniversityJ. Tiao (Author/Creator) - Murdoch UniversityQ. Hughes (Author/Creator) - Murdoch UniversityG. Gilmore (Author/Creator) - Gulf Coast Regional Blood CenterR. Baker (Author/Creator) - Murdoch University
- Publication Details
- Australian Journal of Chemistry, Vol.69(10), pp.1078-1093
- Publisher
- Commonwealth Scientific and Industrial Research Organization Publishing
- Identifiers
- 991005542115307891
- Murdoch Affiliation
- Centre for Haemophilia and Thrombosis Research
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 1 Clinical & Life Sciences
- 1.196 Micro & Long Noncoding RNA
- 1.196.68 MicroRNA in Cancer
- Web Of Science research areas
- Chemistry, Multidisciplinary
- ESI research areas
- Chemistry