Journal article
Therapeutic potential of neurogenesis and melatonin regulation in Alzheimer's disease
Annals of the New York Academy of Sciences, Vol.1478(1), pp.43-62
2020
Abstract
Alzheimer's disease (AD) is an age-related neurodegenerative disorder characterized by the hallmark pathologies of amyloid-beta plaques and neurofibrillary tangles. Symptoms of this devastating disease include behavioral changes and deterioration of higher cognitive functions. Impairment of neurogenesis has also been shown to occur in AD, which adversely impacts new neuronal cell growth, differentiation, and survival. This impairment possibly results from the cumulative effects of the various pathologies of AD. Preclinical studies have suggested that the administration of melatonin—the pineal hormone primarily responsible for the regulation of the circadian rhythm—targets the effects of AD pathologies and improves cognitive impairment. It is postulated that by mitigating the effect of these pathologies, melatonin can also rescue neurogenesis impairment. This review aims to explore the effect of AD pathologies on neurogenesis, as well as the mechanisms by which melatonin is able to ameliorate AD pathologies to potentially promote neurogenesis.
Details
- Title
- Therapeutic potential of neurogenesis and melatonin regulation in Alzheimer's disease
- Authors/Creators
- M. Mihardja (Author/Creator) - University of Hong KongJ. Roy (Author/Creator) - University of Hong KongK.Y. Wong (Author/Creator) - University of Hong KongL. Aquili (Author/Creator)B.C. Heng (Author/Creator) - Sunway UniversityY‐S Chan (Author/Creator) - University of Hong KongM.L. Fung (Author/Creator) - University of Hong KongL.W. Lim (Author/Creator) - Sunway University
- Publication Details
- Annals of the New York Academy of Sciences, Vol.1478(1), pp.43-62
- Publisher
- Blackwell Publishing Inc.
- Identifiers
- 991005543255307891
- Copyright
- © 2020 New York Academy of Sciences.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Metrics
43 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.137 Sleep Science & Circadian Systems
- 1.137.217 Circadian-Melatonin
- Web Of Science research areas
- Neurosciences
- ESI research areas
- Neuroscience & Behavior