Journal article
There is detectable variation in the lipidomic profile between stable and progressive patients with idiopathic pulmonary fibrosis (IPF)
Respiratory Research, Vol.22(1), Art. 105
2021
Abstract
Background
Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease characterized by fibrosis and progressive loss of lung function. The pathophysiological pathways involved in IPF are not well understood. Abnormal lipid metabolism has been described in various other chronic lung diseases including asthma and chronic obstructive pulmonary disease (COPD). However, its potential role in IPF pathogenesis remains unclear.
Methods
In this study, we used ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS) to characterize lipid changes in plasma derived from IPF patients with stable and progressive disease. We further applied a data-independent acquisition (DIA) technique called SONAR, to improve the specificity of lipid identification.
Results
Statistical modelling showed variable discrimination between the stable and progressive subjects, revealing differences in the detection of triglycerides (TG) and phosphatidylcholines (PC) between progressors and stable IPF groups, which was further confirmed by mass spectrometry imaging (MSI) in IPF tissue.
Conclusion
This is the first study to characterise lipid metabolism between stable and progressive IPF, with results suggesting disparities in the circulating lipidome with disease progression.
Details
- Title
- There is detectable variation in the lipidomic profile between stable and progressive patients with idiopathic pulmonary fibrosis (IPF)
- Authors/Creators
- S. Nambiar (Author/Creator) - Murdoch UniversityB. Clynick (Author/Creator) - The University of Western AustraliaS-H Bong (Author/Creator)A. King (Author/Creator) - Waters (United States)E.H. Walters (Author/Creator) - The Alfred HospitalN.S. Goh (Author/Creator) - Austin HospitalT.J. Corte (Author/Creator) - Royal Prince Alfred HospitalR. Trengove (Author/Creator) - Murdoch UniversityD. Tan (Author/Creator) - The University of Western AustraliaY. Moodley (Author/Creator) - Fiona Stanley Hospital
- Publication Details
- Respiratory Research, Vol.22(1), Art. 105
- Publisher
- BioMed Central
- Identifiers
- 991005544921707891
- Copyright
- © 2021 The Authors.
- Murdoch Affiliation
- Separation Science and Metabolomics Laboratory
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Metrics
68 File views/ downloads
74 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Industry collaboration
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.208 Vasculitis & Autoimmune Disorders
- 1.208.1262 Idiopathic Pulmonary Fibrosis
- Web Of Science research areas
- Respiratory System
- ESI research areas
- Clinical Medicine