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Open Access CC BY V4.0
Journal article
Thin and hypokinetic myocardial segments in cats with cardiomyopathy
Journal of veterinary cardiology, Vol.46, pp.5-17
2023
PMID: 36893525
Abstract
Introduction/objectives: Thin and hypokinetic myocardial segments (THyMS) represent adverse ventricular (LV) remodeling in human hypertrophic cardiomyopathy. We describe the echocardiographic features and outcome in cats with THyMS, and in a subpopulation, the echocardiographic phenotype before LV wall thinning was detected (pre-THyMS).
Animals: Eighty client-owned cats. Materials and methods: Retrospective multicenter study. Clinical records were searched for cats with THyMS, defined as LV segment(s) with end-diastolic wall thickness (LVWT) <3 mm and hypokinesis in the presence of ≥one LV segment(s) with LVWT >4 mm and normal wall motion. When available, echocardiograms pre-THyMS were assessed. Survival time was defined as time from first presentation with THyMS to death.
Results: Mean thickest LV wall segment (MaxLVWT) was 6.1 mm (95% CI 5.8–6.4 mm) and thinnest (MinLVWT) was 1.7 mm (95% CI 1.6–1.9 mm). The LV free wall was affected in 74%, apex in 13% and septum in 5%. Most cats (85%) presented with heart failure and/or arterial thromboembolism. Median circulating troponin I concentration was 1.4 ng/mL ([range 0.07–180 ng/mL]). Prior echocardiography results were available for 13/80 cats, a mean of 2.5 years pre-THyMS. In segments subsequently undergoing thinning, initial MaxLVWT measured 6.7 mm (95% CI 5.8–7.7 mm) vs. 1.9 mm (95% CI 1.5–2.4 mm) at last echocardiogram (P<0.0001). Survival data were available for 56/80 cats, median survival time after diagnosing THyMS was 153 days (95% CI 83–223 days). Cardiac histopathology in one cat revealed that THyMS was associated with severe transmural scarring.
Conclusions: Cats with THyMS had advanced cardiomyopathy and a poor prognosis.
Details
- Title
- Thin and hypokinetic myocardial segments in cats with cardiomyopathy
- Authors/Creators
- J. Novo Matos - Clinical Science and Services, Royal Veterinary College, London, Hertfordshire, United KingdomJ. Sargent - Southern Counties Veterinary Specialists, Unit 6, Ringwood, Hampshire, United KingdomJ. Silva - North Downs Specialist Referrals, Bletchingley, Surrey, United KingdomJ. R. Payne - Langford Vets Small Animal Referral Hospital, University of Bristol, Langford, United KingdomJ. Seo - Animal Referral Centre, Auckland, New ZealandI. Spalla - Ospedale Veterinario San Francesco, Milan, ItalyK. Borgeat - Langford Vets Small Animal Referral Hospital, University of Bristol, Langford, United KingdomJ. Loureiro - North Downs Specialist Referrals, Bletchingley, Surrey, United KingdomN. Pereira - Freelance Cardiology, Winterthur, SwitzerlandI. C. Simcock - NIHR Great Ormond Street Hospital Biomedical Research Centre, Great Ormond Street Hospital Biomedical Research Centre, London, United KingdomJ. C. Hutchinson - NIHR Great Ormond Street Hospital Biomedical Research Centre, Great Ormond Street Hospital Biomedical Research Centre, London, United KingdomO. J. Arthurs - NIHR Great Ormond Street Hospital Biomedical Research Centre, Great Ormond Street Hospital Biomedical Research Centre, London, United KingdomV. Luis Fuentes - Clinical Science and Services, Royal Veterinary College, London, Hertfordshire, United Kingdom
- Publication Details
- Journal of veterinary cardiology, Vol.46, pp.5-17
- Publisher
- Elsevier B.V.
- Number of pages
- 13
- Identifiers
- 991005913051007891
- Copyright
- © 2023 The Author(s).
- Murdoch Affiliation
- School of Veterinary Medicine
- Language
- English
- Resource Type
- Journal article
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