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Thrombosis in systemic lupus erythematosus
Journal article   Peer reviewed

Thrombosis in systemic lupus erythematosus

A. Palatinus and M. Adams
Seminars in Thrombosis and Hemostasis, Vol.35(07), pp.621-629
2009
DOI: https://doi.org/10.1055/s-0029-1242716
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Abstract

Systemic lupus erythematosus (SLE) is a potentially fatal multiorgan inflammatory disease that primarily affects females. Due to the heterogeneity of clinical manifestations and lack of laboratory tests that are both specific and sensitive for the disease, diagnosis of SLE can often be difficult. Although the precise etiology remains to be fully elucidated, it is probable that various environmental, genetic, and hormonal factors contribute to the development of the disease. Patients with SLE have an increased risk for premature thrombosis and/or atherosclerosis, with up to half experiencing a thrombotic event. Furthermore, antiphospholipid antibodies probably play a key role in the development of thrombosis by affecting various hemostatic protein interactions with phospholipids and cell surfaces as well as platelet function. Despite recent advances in knowledge related to the factors that contribute to the pathophysiology of SLE, numerous challenges related to earlier diagnosis as well as the prediction and prevention of thrombotic events remain to be fully addressed.

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UN Sustainable Development Goals (SDGs)

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#3 Good Health and Well-Being

Source: InCites

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22 Record Views
53 Times Cited - Web of Science

InCites Highlights

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Citation topics
1 Clinical & Life Sciences
1.106 Rheumatology
1.106.478 Systemic Lupus Erythematosus
Web Of Science research areas
Hematology
Peripheral Vascular Disease
ESI research areas
Clinical Medicine
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