Tiletamine/Zolazepam and Ketamine with Dexmedetomidine (TKD) Cocktail Is as Effective as Tiletamine/Zolazepam and Ketamine with Xylazine (TKX) in Providing Pig General Anesthesia

Ekkapol Akaraphutiporn; Sumit Durongphongtorn; Katechan Jampachaisri; Patrick Sharp; Cholawat Pacharinsak; Chalika Wangdee

doi:10.3390/ani14192881

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Tiletamine/Zolazepam and Ketamine with Dexmedetomidine (TKD) Cocktail Is as Effective as Tiletamine/Zolazepam and Ketamine with Xylazine (TKX) in Providing Pig General Anesthesia

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Tiletamine/Zolazepam and Ketamine with Dexmedetomidine (TKD) Cocktail Is as Effective as Tiletamine/Zolazepam and Ketamine with Xylazine (TKX) in Providing Pig General Anesthesia

Ekkapol Akaraphutiporn, Sumit Durongphongtorn, Katechan Jampachaisri, Patrick Sharp, Cholawat Pacharinsak and Chalika Wangdee

Animals (Basel), Vol.14(19), 2881

2024

DOI: https://doi.org/10.3390/ani14192881

PMID: 39409830

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Abstract

dexmedetomidine

xylazine

tiletamine/zolazepam

anesthesia

pig

This study aimed to evaluate dexmedetomidine as an alternative to xylazine in pigs. We compared TKD (0.05 mL/kg) to TKX (0.05 mL/kg) in 20 male pigs undergoing unilateral cryptorchid castration (short-term, 45-min) or bilateral cryptorchid castration (long-term, 90-min). We hypothesized that TKD would be comparable to TKX for both short-term and long-term anesthesia. Monitored parameters were classified into duration and physiological categories, including induction and recovery times, reflexes, heart rate (HR), respiratory rate (RR), arterial blood pressure, oxygen saturation (%SpO2), end-tidal carbon dioxide (ETCO2), and body temperature (TEMP). Isoflurane levels were also recorded, if used. Results showed no significant differences in duration parameters between TKD and TKX for either short-term or long-term anesthesia (induction: 1 min; recovery: 18-35 min). Physiological parameters were mostly similar between groups, although TKD caused slightly higher blood pressure during short-term anesthesia. Isoflurane levels (0.1-0.6%) were comparable between groups. Overall, the results suggest that TKD provides anesthesia comparable to TKX in pigs undergoing unilateral or bilateral cryptorchid surgery requiring short-term and long-term anesthesia.

Details

Title: Tiletamine/Zolazepam and Ketamine with Dexmedetomidine (TKD) Cocktail Is as Effective as Tiletamine/Zolazepam and Ketamine with Xylazine (TKX) in Providing Pig General Anesthesia
Authors/Creators: Ekkapol Akaraphutiporn - Chulalongkorn University
Sumit Durongphongtorn - Chulalongkorn University
Katechan Jampachaisri - Naresuan University
Patrick Sharp - University of California, Merced
Cholawat Pacharinsak - Stanford University
Chalika Wangdee - Chulalongkorn University
Publication Details: Animals (Basel), Vol.14(19), 2881
Publisher: MDPI
Number of pages: 10
Identifiers: 991005707253207891
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.43 Anesthesiology; 1.43.1642 Veterinary Anesthesia
Web Of Science research areas: Agriculture, Dairy & Animal Science; Veterinary Sciences; Zoology
ESI research areas: Plant & Animal Science