Journal article
Tissue factor pathway inhibitor: Then and now
Seminars in Thrombosis and Hemostasis, Vol.40(08), pp.881-886
2014
Abstract
Tissue factor pathway inhibitor (TFPI) is the major physiological regulator of tissue factor (TF)-induced blood coagulation. TFPI inhibits the TF-activated factor VII (FVIIa) complex in an activated factor X (FXa)-dependent manner, helping to control thrombin generation and ultimately fibrin formation. The importance of TFPI is demonstrated in models of hemophilia where lower levels of FVIII or FIX are insufficient to overcome its inhibitory effect, resulting in a bleeding phenotype. There are two major isoforms in vivo; TFPIα contains three Kunitz-type inhibitory domains (designated K1, K2, and K3), is secreted by endothelial cells and requires protein S to enhance its anticoagulant activity. In contrast, TFPIβ contains only the K1 and K2 domains, but it is attached to the endothelial surface via a glycosylphosphatidylinositol anchor. This review will initially provide a brief history of the major discoveries related to TFPI, and then discuss new insights into the physiology of TFPI, including updates on its association with protein S and FV, as well as the current understanding of its association with disease.
Details
- Title
- Tissue factor pathway inhibitor: Then and now
- Authors/Creators
- P. Ellery (Author/Creator)M. Adams (Author/Creator) - University of Tasmania
- Publication Details
- Seminars in Thrombosis and Hemostasis, Vol.40(08), pp.881-886
- Publisher
- Thieme Medical Publishers Inc.
- Identifiers
- 991005540062607891
- Copyright
- © 2014
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.75 Blood Clotting
- 1.75.1434 Coagulation Pathways
- Web Of Science research areas
- Hematology
- Peripheral Vascular Disease
- ESI research areas
- Clinical Medicine