Journal article
Tissue oxygen tension and blood-flow changes in rat incisor pulp with graded systemic hyperoxia
Archives of Oral Biology, Vol.47(3), pp.239-246
2002
Abstract
The role of oxygen in the regulation of the pulpal microcirculation is unknown. This investigation is aimed to measure tissue oxygen tension and blood-flow changes in the pulp of rat lower incisors during graded systemic hyperoxia, and to determine the response of the pulpal vasculature to various oxygen tensions. Twenty-four Sprague-Dawley rats were anaesthetized and artificially ventilated with the appropriate gas mixture. Recessed oxygen-sensitive microelectrodes were used to measure pulpal tissue oxygen tension via a small access cavity filled with saline on the labial surface of the incisor. A laser Doppler flowmeter was used to record pulpal blood-flow. Inspired oxygen was increased stepwise from 20 to 100% in 20% steps. Systemic blood-gas concentrations were measured at each step. Systemic arterial oxygen tension at 100% oxygen ventilation reached 481.2 ± 30.7% of the baseline at 20% oxygen breathing (n = 21). Pulpal tissue oxygen tension did not change significantly whereas pulpal blood-flow fell dose-dependently to 74.6 ± 5.0% at 100% oxygen ventilation (n = 21). Systemic hyperoxia, therefore, induces a significant reduction in pulpal blood-flow whereas pulpal tissue oxygen tension remains relatively stable, indicating an oxygen-dependent local regulatory mechanism.
Details
- Title
- Tissue oxygen tension and blood-flow changes in rat incisor pulp with graded systemic hyperoxia
- Authors/Creators
- C.Y. Yu (Author/Creator) - The University of Western AustraliaN.M. Boyd (Author/Creator) - The University of Western AustraliaS.J. Cringle (Author/Creator) - The University of Western AustraliaV.A. Alder (Author/Creator) - Murdoch UniversityD-Y Yu (Author/Creator) - Murdoch University
- Publication Details
- Archives of Oral Biology, Vol.47(3), pp.239-246
- Publisher
- Elsevier
- Identifiers
- 991005542339707891
- Copyright
- © 2002 Elsevier Science Ltd.
- Murdoch Affiliation
- School of Veterinary and Biomedical Sciences
- Language
- English
- Resource Type
- Journal article
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