Journal article
Tissue-specific transcription profile of cytokine and chemokine genes associated with flavivirus control and non-lethal neuropathogenesis in rabbits
Virology, Vol.494, pp.1-14
2016
Abstract
We previously showed that New Zealand White (NZWRs) and cottontail rabbits (CTRs) are a suitable model for studying immune mechanisms behind virus control and non-lethal neuropathogenesis associated with West Nile virus (WNV) and Murray Valley encephalitis virus (MVEV) infections. In the current study, we observed that MVEV infection induced high IFNα, TNFα, IL6, and CXCL10 transcript levels in the brains of weanling NZWRs, unlike infection with the less virulent WNVNSW2011. These transcript levels also correlated with encephalitis severity. Widespread STAT1 protein expression in brain with moderate neuropathology suggests that IFN-I signaling is crucial for limiting neural infection and mediating non-lethal neuropathogenesis. Unlike NZWRs, CTRs limit neuroinvasion without upregulation of many cytokine/chemokine transcripts, suggesting a species-dependent virus control mechanism. However, the common IFNγ, TNFα and IL6 transcript upregulation in specific lymphoid organs suggest some conserved elements in the response against flaviviruses, unique to all rabbits.
Details
- Title
- Tissue-specific transcription profile of cytokine and chemokine genes associated with flavivirus control and non-lethal neuropathogenesis in rabbits
- Authors/Creators
- W.W. Suen (Author/Creator) - The University of QueenslandM.J. Uddin (Author/Creator) - The University of QueenslandN.A. Prow (Author/Creator) - The University of QueenslandR.A. Bowen (Author/Creator) - Colorado State UniversityR.A. Hall (Author/Creator) - The University of QueenslandH. Bielefeldt-Ohmann (Author/Creator) - The University of Queensland
- Publication Details
- Virology, Vol.494, pp.1-14
- Publisher
- Elsevier
- Identifiers
- 991005542707807891
- Copyright
- © 2016 Elsevier Inc.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
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- Citation topics
- 1 Clinical & Life Sciences
- 1.228 Virology - Tropical Diseases
- 1.228.200 Mosquito-borne Viruses
- Web Of Science research areas
- Virology
- ESI research areas
- Microbiology