Journal article
Tolerance of Pseudomonas aeruginosa to Melaleuca alternifolia (tea tree) oil is associated with the outer membrane and energy-dependent cellular processes
Journal of Antimicrobial Chemotherapy, Vol.54(2), pp.386-392
2004
Abstract
Objectives: The essential oil of Melaleuca alternifolia (tea tree oil) and its components have antimicrobial activity against a wide range of Gram-positive and Gram-negative bacteria, fungi and viruses. The mechanism(s) by which Pseudomonas aeruginosa NCTC 10662 maintains a decreased susceptibility to tea tree oil and components was investigated.
Results: Ethylene diamine tetraacetic acid enhanced the antimicrobial activity of tea tree oil and terpinen-4-ol against stationary phase P. aeruginosa while polymyxin B nonapeptide enhanced the activity of tea tree oil and γ-terpinene. Pre-treatment with the protonophore carbonyl cyanide m-chlorophenylhydrazone increased the susceptibility of exponential phase cells to sub-inhibitory concentrations of tea tree oil, terpinen-4-ol and γ-terpinene, indicating that intrinsic tolerance to tea tree oil and components is substantially energy dependent.
Conclusions: Increased tolerance to tea tree oil in P. aeruginosa is directly related to the barrier and energy functions of the outer membrane, and may involve efflux systems.
Details
- Title
- Tolerance of Pseudomonas aeruginosa to Melaleuca alternifolia (tea tree) oil is associated with the outer membrane and energy-dependent cellular processes
- Authors/Creators
- C.J. Longbottom (Author/Creator) - School of Molecular SciencesC.F. Carson (Author/Creator) - School of Medicine and PharmacologyK.A. Hammer (Author/Creator) - School of Pathology and Laboratory MedicineB.J. Mee (Author/Creator) - School of Pathology and Laboratory MedicineT.V. Riley (Author/Creator) - School of Pathology and Laboratory Medicine
- Publication Details
- Journal of Antimicrobial Chemotherapy, Vol.54(2), pp.386-392
- Publisher
- Oxford University Press
- Identifiers
- 991005541505207891
- Copyright
- © 2004 The British Society for Antimicrobial Chemotherapy
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 3 Agriculture, Environment & Ecology
- 3.16 Phytochemicals
- 3.16.314 Essential Oil
- Web Of Science research areas
- Infectious Diseases
- Microbiology
- Pharmacology & Pharmacy
- ESI research areas
- Pharmacology & Toxicology