Journal article
Toll-like receptor (TLR) expression on CD4+ and CD8+ T-cells in patients chronically infected with hepatitis C virus
Cellular Immunology, Vol.264(2), pp.150-155
2010
Abstract
Toll-like receptor (TLR) expression on T-cells and the signalling pathways that lead to the production of cytokines may limit antigen-specific T-cell responses. Here, expression of TLR and retinoic acid inducible gene I (RIG-I) on T-cells were evaluated in patients chronically infected with hepatitis C virus (HCV), before and during pegylated interferon-α and ribavirin therapy. Expression of TLR2,3,4,7,9 and retinoic acid inducible gene (RIG)-I on different CD4+ and CD8+ T-cell sub-populations (naïve: CD45RA+CD57−; central memory: TCM CD45RA−CD57−; effector memory: TEM CD45RA−CD57+ and terminally differentiated effector memory: TEMRA CD45RA+CD57+) were measured by flow cytometry. TLR7, TLR9 and RIG-I expression on CD4+ T-cells and RIG-I expression on CD8+ T-cells was higher in patients than healthy controls. Therapy increased expression of TLR2, TLR4 and TLR9 and this was observed for all T-cell sub-populations. Evaluation of TLR expression at baseline did not identify patients able to achieve sustained virological response following therapy.
Details
- Title
- Toll-like receptor (TLR) expression on CD4+ and CD8+ T-cells in patients chronically infected with hepatitis C virus
- Authors/Creators
- T. Hammond (Author/Creator) - The University of Western AustraliaS. Lee (Author/Creator) - Royal Perth HospitalM.W. Watson (Author/Creator) - Royal Perth HospitalJ.P. Flexman (Author/Creator) - The University of Western AustraliaW. Cheng (Author/Creator) - Royal Perth HospitalS. Fernandez (Author/Creator) - The University of Western AustraliaP. Price (Author/Creator) - Royal Perth Hospital
- Publication Details
- Cellular Immunology, Vol.264(2), pp.150-155
- Publisher
- Academic Press Inc.
- Identifiers
- 991005541283407891
- Copyright
- © 2010 Published by Elsevier Inc.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 1 Clinical & Life Sciences
- 1.6 Immunology
- 1.6.609 Toll-like Receptors
- Web Of Science research areas
- Cell Biology
- Immunology
- ESI research areas
- Immunology