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Torsion-induced injury in rat testes does not affect mitochondrial respiration or the accumulation of mitochondrial mutations
Journal article   Peer reviewed

Torsion-induced injury in rat testes does not affect mitochondrial respiration or the accumulation of mitochondrial mutations

F.A. Ahmed, J. Whelan, A.M. Jequier and J.M. Cummins
International Journal of Andrology, Vol.23(6), pp.347-356
2000
DOI: https://doi.org/10.1046/j.1365-2605.2000.00255.x
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Abstract

Male rats were subjected to 1 h testicular torsion of the spermatic cord or 1 h torsion followed by detorsion and recovery up to 4 weeks. The extent of tissue damage was evaluated by a testicular biopsy score count and mitochondrial function. Torsion for 1 h followed by detorsion induced significant morphological damage, which became more severe with longer periods of recovery. This morphological damage could not be correlated with mitochondrial damage as assessed by measuring the 4834 bp mitochondrial DNA ‘common deletion’ using a quantitative competitive polymerase chain reaction (PCR) assay. Mitochondrial respiratory chain activity, as measured by mitochondrial oxygen consumption using an oxygen electrode, did not vary between the treated animals and the controls. We conclude that the common mitochondrial DNA deletion and oxygen consumption are not good indicators of testicular damage induced by torsion.

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Source: InCites

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17 Record Views
15 Times Cited - Web of Science

InCites Highlights

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Collaboration types
Domestic collaboration
Citation topics
1 Clinical & Life Sciences
1.291 Testicular Diseases
1.291.779 Testicular Cancer
Web Of Science research areas
Andrology
ESI research areas
Clinical Medicine
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