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Toxicity in three dogs from accidental oral administration of a topical endectocide containing moxidectin and imidacloprid
Journal article   Peer reviewed

Toxicity in three dogs from accidental oral administration of a topical endectocide containing moxidectin and imidacloprid

A.M. See, S.E. McGill, A.L. Raisis and K.L. Swindells
Australian Veterinary Journal, Vol.87(8), pp.334-337
2009
DOI: https://doi.org/10.1111/j.1751-0813.2009.00448.x
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Abstract

Three dogs were presented with a history of oral administration of a topical endectocide containing imidacloprid and moxidectin. They were diagnosed with imidacloprid and moxidectin intoxication, having ingested doses ranging from 7.5 to 1.4 mg/kg of imidacloprid and 1.9 to 2.8 mg/kg of moxidectin. The three dogs were affected to different degrees of severity, but all displayed signs of ataxia, generalised muscle tremors, paresis, hypersalivation and disorientation. Temporary blindness occurred in two cases. The three dogs were tested for the presence of the multi-drug resistance 1 gene deletion, which can cause an increased sensitivity to the toxic effects of moxidectin, and were found to be negative. Treatment included gastrointestinal decontamination, intravenous fluid therapy and benzodiazepines to control muscle tremors. All three dogs made a complete recovery within 48 h of ingestion.

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Source: InCites

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Citation topics
1 Clinical & Life Sciences
1.163 Parasitology - General
1.163.1022 Anthelmintic Resistance
Web Of Science research areas
Veterinary Sciences
ESI research areas
Plant & Animal Science
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