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CC BY V4.0, Open Access
Journal article
Traditional medicinal plants in the treatment of gastrointestinal parasites in humans: A systematic review and meta-analysis of clinical and experimental evidence
Phytotherapy research, Vol.37(9), pp.3675-3687
2023
PMID: 37230485
Appears in Open Access via Read & Publish Agreements
Abstract
Gastrointestinal (GI) parasites cause significant morbidity and mortality worldwide. The use of conventional antiparasitic drugs is often inhibited due to limited availability, side effects or parasite resistance. Medicinal plants can be used as alternatives or adjuncts to current antiparasitic therapies. This systematic review and meta-analysis aimed to critically synthesise the literature on the efficacy of different plants and plant compounds against common human GI parasites and their toxicity profiles. Searches were conducted from inception to September 2021. Of 5393 screened articles, 162 were included in the qualitative synthesis (159 experimental studies and three randomised control trials [RCTs]), and three articles were included in meta-analyses. A total of 507 plant species belonging to 126 families were tested against different parasites, and most of these (78.4%) evaluated antiparasitic efficacy in vitro. A total of 91 plant species and 34 compounds were reported as having significant in vitro efficacy against parasites. Only a few plants (n = 57) were evaluated for their toxicity before testing their antiparasitic effects. The meta-analyses revealed strong evidence of the effectiveness of Lepidium virginicum L. against Entamoeba histolytica with a pooled mean IC50 of 198.63 μg/mL (95% CI 155.54–241.72). We present summary tables and various recommendations to direct future research.
Details
- Title
- Traditional medicinal plants in the treatment of gastrointestinal parasites in humans: A systematic review and meta-analysis of clinical and experimental evidence
- Authors/Creators
- Sandamalie Ranasinghe - Murdoch UniversitySasha Aspinall - Murdoch University, School of Allied HealthAmber Beynon - Macquarie UniversityAmanda Ash - Murdoch University, Centre for Biosecurity and One HealthAlan Lymbery - Murdoch University, Centre for Sustainable Aquatic Ecosystems
- Publication Details
- Phytotherapy research, Vol.37(9), pp.3675-3687
- Publisher
- John Wiley & Sons Ltd.
- Number of pages
- 13
- Grant note
- RTP Scholarship Australia
- Identifiers
- 991005583170107891
- Copyright
- © 2023 The Authors
- Murdoch Affiliation
- Centre for Biosecurity and One Health; School of Environmental and Conservation Sciences; Centre for Sustainable Aquatic Ecosystems; School of Medical, Molecular and Forensic Sciences; School of Allied Health
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.163 Parasitology - General
- 1.163.1022 Anthelmintic Resistance
- Web Of Science research areas
- Chemistry, Medicinal
- Pharmacology & Pharmacy
- ESI research areas
- Pharmacology & Toxicology