Transcorneal electrical stimulation enhances cognitive functions in aged and 5XFAD mouse models

Wing Shan Yu; Luca Aquili; Kah Hui Wong; Amy Cheuk Yin Lo; Leanne Lai Hang Chan; Ying‐Shing Chan; Lee Wei Lim

doi:10.1111/nyas.14850

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Transcorneal electrical stimulation enhances cognitive functions in aged and 5XFAD mouse models

Journal article

Peer reviewed

Transcorneal electrical stimulation enhances cognitive functions in aged and 5XFAD mouse models

Wing Shan Yu, Luca Aquili, Kah Hui Wong, Amy Cheuk Yin Lo, Leanne Lai Hang Chan, Ying‐Shing Chan and Lee Wei Lim

Annals of the New York Academy of Sciences, Vol.1515(1), pp.249-265

2022

DOI: https://doi.org/10.1111/nyas.14850

PMID: 35751874

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Abstract

5XFAD mouse model

Alzheimer's disease

dementia

PSD95

synaptic component

transcorneal electrical stimulation (TES)

Dementia is a major burden on global health for which there are no effective treatments. The use of noninvasive visual stimulation to ameliorate cognitive deficits is a novel concept that may be applicable for treating dementia. In this study, we investigated the effects of transcorneal electrical stimulation (TES) on memory enhancement using two mouse models, in aged mice and in the 5XFAD model of Alzheimer's disease. After 3 weeks of TES treatment, mice were subjected to Y-maze and Morris water maze tests to assess hippocampal-dependent learning and memory. Immunostaining of the hippocampus of 5XFAD mice was also performed to examine the effects of TES on amyloid plaque pathology. The results showed that TES improved the performance of both aged and 5XFAD mice in memory tests. TES also reduced hippocampal plaque deposition in male, but not female, 5XFAD mice. Moreover, TES significantly reversed the downregulated level of postsynaptic protein 95 in the hippocampus of male 5XFAD mice, suggesting the effects of TES involve a postsynaptic mechanism. Overall, these findings support further investigation of TES as a potential treatment for cognitive dysfunction and mechanistic studies of TES effects in other dementia models.

Details

Title: Transcorneal electrical stimulation enhances cognitive functions in aged and 5XFAD mouse models
Authors/Creators: Wing Shan Yu - University of Hong Kong
Luca Aquili - Murdoch University
Kah Hui Wong - Chinese University of Hong Kong
Amy Cheuk Yin Lo - Chinese University of Hong Kong
Leanne Lai Hang Chan - City University of Hong Kong
Ying‐Shing Chan - Chinese University of Hong Kong
Lee Wei Lim - University of Hong Kong
Publication Details: Annals of the New York Academy of Sciences, Vol.1515(1), pp.249-265
Number of pages: 17
Grant note: Seed Fund for Translational & Applied Research, The University of Hong Kong (201910160010) Seed Fund for Basic Research, The University of Hong Kong (201811159133; 201910159163) Research Grants Council, University Grants Committee (17119420)
Identifiers: 991005591572007891
Murdoch Affiliation: College of Health and Education; School of Psychology
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.52 Neurodegenerative Diseases; 1.52.57 Alzheimer's Mechanisms
Web Of Science research areas: Neurosciences
ESI research areas: Neuroscience & Behavior