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Published (Version of Record)CC BY V4.0, Open Access
Journal article
Transcriptomic Profiling of Influenza A Virus-Infected Mouse Lung at Recovery Stage Using RNA Sequencing
Viruses, Vol.15(11), 2198
2023
Abstract
Influenza A virus (IAV) is known to cause mild to severe respiratory illness. Under some conditions, the infection can lead to pneumonia (viral or bacterial), acute respiratory distress syndrome, and other complications that can be fatal, especially in vulnerable populations such as the elderly, young children, and individuals with underlying health conditions. Despite previous studies, little is known about the host immune response and neuroimmune interactions in IAV infection. Using RNA sequencing, we performed transcriptomic analysis of murine lung tissue 21 days post infection (dpi) with IAV (H1N1) in order to find the differentially expression genes (DEGs) related to the host immune response and neuroimmune interactions inside the lung during recovery. Among 792 DEGs, 434 genes were up-regulated, whereas 358 genes were down-regulated. The most prominent molecular functions of the up-regulated genes were related to the immune response and tissue repair, whereas a large proportion of the down-regulated genes were associated with neural functions. Although further molecular/functional studies need to be performed for these DEGs, our results facilitate the understanding of the host response (from innate immunity to adaptive immunity) and neuroimmune interactions in infected lungs at the recovery stage of IAV infection. These genes might have potential uses as mechanistic/diagnostic biomarkers and represent possible targets for anti-IAV therapies.
Details
- Title
- Transcriptomic Profiling of Influenza A Virus-Infected Mouse Lung at Recovery Stage Using RNA Sequencing
- Authors/Creators
- Huda A. M. Al-Shalan - Murdoch UniversityDailun Hu - Hebei Medical UniversityPenghao Wang - Murdoch UniversityJasim UddinAbha Chopra - Murdoch UniversityWayne K. Greene - Murdoch UniversityBin Ma - Murdoch University
- Publication Details
- Viruses, Vol.15(11), 2198
- Publisher
- MDPI
- Identifiers
- 991005611562107891
- Copyright
- © 2023 by the authors
- Murdoch Affiliation
- Centre for Crop and Food Innovation; Centre for Animal Production and Health; Harry Butler Institute; Centre for Molecular Medicine and Innovative Therapeutics; School of Veterinary Medicine
- Language
- English
- Resource Type
- Journal article
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