Journal article
Transdermal methimazole treatment in cats with hyperthyroidism
Journal of feline medicine and surgery, Vol.5(2), pp.77-82
2003
PMID: 12670432
Abstract
The objectives of this study were to assess serum thyroxine concentrations and clinical response in hyperthyroid cats to treatment with transdermal methimazole, and to determine if further investigation is indicated.
Clinical and laboratory data from 13 cats with hyperthyroidism were retrospectively evaluated. Methimazole (Tapazole, Eli Lilly) was formulated in a pleuronic lecithin organogel (PLO)-based vehicle and was applied to the inner pinna of the ear at a dosage ranging from 2.5 mg/cat q 24 h to 10.0 mg/cat q 12 h. During the treatment period, cats were re-evaluated at a mean of 4.3 weeks (recheck-1), and again at a mean of 5.4 months (recheck-2).
Clinical improvement was observed, and significant decreases in thyroxine concentrations were measured at recheck-1 (mean: 39.57 nmol/L, SEM: 14.4, SD: 41.2) and recheck-2 (mean: 36.71 nmol/L, SEM: 13.9, SD: 45.56) compared to pretreatment concentrations (mean: 97.5 nmol/L, SEM: 11.42, SD: 39.5). No adverse effects were reported.
Details
- Title
- Transdermal methimazole treatment in cats with hyperthyroidism
- Authors/Creators
- G Hoffmann - Louisiana State UniversityS L Marks - Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 708030/8410, USAJ Taboada - Louisiana State UniversityG L Hosgood - Louisiana State UniversityK J Wolfsheimer - Endocrine Diagnostics & Consultation, 5305 Flanders Drive, Baton Rouge, LA 70808, USA
- Publication Details
- Journal of feline medicine and surgery, Vol.5(2), pp.77-82
- Identifiers
- 991005592770207891
- Copyright
- © 2003 International Society of Feline Medicine and American Association of Feline Practitioners
- Murdoch Affiliation
- School of Veterinary Medicine
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.213 Thyroid Disorders
- 1.213.168 Thyroid Disorders
- Web Of Science research areas
- Veterinary Sciences
- ESI research areas
- Plant & Animal Science