Translational perspectives on neurophysiological responses and mechanisms in blood flow restriction exercise

Kai T Fox; Luke Hughes; Brendan R Scott; Paul S R Goods; Shaun Ym Teo; Ann-Maree Vallence

doi:10.1113/EP093587

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Translational perspectives on neurophysiological responses and mechanisms in blood flow restriction exercise

Journal article

Open access

Peer reviewed

Translational perspectives on neurophysiological responses and mechanisms in blood flow restriction exercise

Kai T Fox, Luke Hughes, Brendan R Scott, Paul S R Goods, Shaun Ym Teo and Ann-Maree Vallence

Experimental physiology, Early View

2026

DOI: https://doi.org/10.1113/EP093587

PMID: 42303276

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Abstract

functional ability

hypoxia

ischaemia

neuroplasticity

Maintaining corticospinal tract function is crucial for voluntary movement. Exercise using high external loads/intensities is a promising intervention to promote adaptations to the corticospinal tract and improve physical function; however, such loads/intensities may not be tolerable or safe in populations with neurological disorders, motor-impaired injuries and older adults. Exercise using low external loads/intensities with blood flow restriction offers an alternative that provides comparable adaptations in muscular hypertrophy, strength and function (e.g., gait performance) to higher external-load/intensity exercise. Although some data suggest that blood flow restriction exercise may induce neuroplasticity, the neurophysiological responses remain largely unknown. Given the potential significance of blood flow restriction exercise for clinical populations, this review synthesises available data and potential mechanisms of these neuroplastic responses while providing translational insights and future research recommendations.

Details

Title: Translational perspectives on neurophysiological responses and mechanisms in blood flow restriction exercise
Authors/Creators: Kai T Fox - Murdoch University
Luke Hughes - Northumbria University
Brendan R Scott - Murdoch University
Paul S R Goods - Murdoch University
Shaun Ym Teo - Murdoch University
Ann-Maree Vallence - Murdoch University
Publication Details: Experimental physiology, Early View
Publisher: John Wiley & Sons Ltd on behalf of The Physiological Society.; HOBOKEN
Number of pages: 10
Grant note: Murdoch International Postgraduate Scholarship
Identifiers: 991005895972407891
Murdoch Affiliation: School of Psychology; Murdoch Applied Sports Science Laboratory; Centre for Healthy Ageing; School of Allied Health
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.82 Gait & Posture; 1.82.811 Transcranial Magnetic Stimulation
Web Of Science research areas: Physiology
ESI research areas: Biology & Biochemistry