Transplacental innate immune training via maternal microbial exposure: Role of XBP1-ERN1 axis in dendritic cell precursor programming

K.T. Mincham; A.C. Jones; M. Bodinier; N.M. Scott; J-F Lauzon-Joset; P.A. Stumbles; A. Bosco; P.G. Holt; D.H. Strickland

doi:10.3389/fimmu.2020.601494

Back

Transplacental innate immune training via maternal microbial exposure: Role of XBP1-ERN1 axis in dendritic cell precursor programming

Journal article

Open access

Peer reviewed

Transplacental innate immune training via maternal microbial exposure: Role of XBP1-ERN1 axis in dendritic cell precursor programming

K.T. Mincham, A.C. Jones, M. Bodinier, N.M. Scott, J-F Lauzon-Joset, P.A. Stumbles, A. Bosco, P.G. Holt and D.H. Strickland

Frontiers in Immunology, Vol.11, Art. 1494

2020

DOI: https://doi.org/10.3389/fimmu.2020.601494

Files and links (2)

pdf

XBP1ERN1.pdfDownload View

Published (Version of Record) Open Access

url

Free to Read *No subscription requiredView

Abstract

We recently reported that offspring of mice treated during pregnancy with the microbial-derived immunomodulator OM-85 manifest striking resistance to allergic airways inflammation, and localized the potential treatment target to fetal conventional dendritic cell (cDC) progenitors. Here, we profile maternal OM-85 treatment-associated transcriptomic signatures in fetal bone marrow, and identify a series of immunometabolic pathways which provide essential metabolites for accelerated myelopoiesis. Additionally, the cDC progenitor compartment displayed treatment-associated activation of the XBP1-ERN1 signalling axis which has been shown to be crucial for tissue survival of cDC, particularly within the lungs. Our forerunner studies indicate uniquely rapid turnover of airway mucosal cDCs at baseline, with further large-scale upregulation of population dynamics during aeroallergen and/or pathogen challenge. We suggest that enhanced capacity for XBP1-ERN1-dependent cDC survival within the airway mucosal tissue microenvironment may be a crucial element of OM-85-mediated transplacental innate immune training which results in postnatal resistance to airway inflammatory disease.

Details

Title: Transplacental innate immune training via maternal microbial exposure: Role of XBP1-ERN1 axis in dendritic cell precursor programming
Authors/Creators: K.T. Mincham (Author/Creator) - The Kids Research Institute Australia
A.C. Jones (Author/Creator) - The Kids Research Institute Australia
M. Bodinier (Author/Creator) - Biopolymères Interactions Assemblages
N.M. Scott (Author/Creator) - The Kids Research Institute Australia
J-F Lauzon-Joset (Author/Creator) - The Kids Research Institute Australia
P.A. Stumbles (Author/Creator) - Murdoch University
A. Bosco (Author/Creator) - The Kids Research Institute Australia
P.G. Holt (Author/Creator) - The Kids Research Institute Australia
D.H. Strickland (Author/Creator) - The Kids Research Institute Australia
Publication Details: Frontiers in Immunology, Vol.11, Art. 1494
Publisher: Frontiers Media
Identifiers: 991005541959807891
Copyright: © 2020 The Authors.
Murdoch Affiliation: School of Medical, Molecular and Forensic Sciences
Language: English
Resource Type: Journal article

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites

Metrics

35 File views/ downloads

33 Record Views

22 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration; International collaboration
Citation topics: 2 Chemistry; 2.1 Synthesis; 2.1.2278 Heterocyclic Synthesis Mechanisms
Web Of Science research areas: Immunology
ESI research areas: Immunology