Journal article
Transplacental transfer of medetomidine and ketamine in pregnant ewes
Laboratory Animals, Vol.46(1), pp.46-50
2012
Abstract
The extent of placental transfer of medetomidine and ketamine is unknown in pregnant ewes. Date-mated singleton (n = 8) and twin (n = 8) pregnant merino cross ewes were anaesthetized for Caesarean delivery of preterm lamb fetuses. A combination of medetomidine (20 mu g/kg) and ketamine (10 mg/kg) was administered by intravenous injection and surgery performed immediately thereafter. Blood samples were collected from the ewe at one, five and 10 min after intravenous injection and from the umbilical vein of the fetus at delivery. Non-pregnant ewes were also anaesthetized (n = 8). There was no difference in the plasma concentration of medetomidine or ketamine when comparing singleton and twin ewes or pregnant and non-pregnant ewes for the short duration of the study. Fetal plasma concentrations of each drug were comparable to the maternal concentrations at the same time. We conclude that both drugs cross the placenta readily and provide anaesthesia and analgesia for the fetus when it is delivered.
Details
- Title
- Transplacental transfer of medetomidine and ketamine in pregnant ewes
- Authors/Creators
- G.C. Musk (Author/Creator)J.D. Netto (Author/Creator)G.L. Maker (Author/Creator)R.D. Trengove (Author/Creator)
- Publication Details
- Laboratory Animals, Vol.46(1), pp.46-50
- Publisher
- Royal Society of Medicine Press
- Identifiers
- 991005543086707891
- Copyright
- © Laboratory Animals Ltd
- Murdoch Affiliation
- Separation Science and Metabolomics Laboratory; School of Pharmacy; School of Veterinary and Biomedical Sciences
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 1 Clinical & Life Sciences
- 1.43 Anesthesiology
- 1.43.1642 Veterinary Anesthesia
- Web Of Science research areas
- Veterinary Sciences
- Zoology
- ESI research areas
- Plant & Animal Science