Logo image
Back
Transudate or exudate: can lactate dehydrogenase activity in canine and feline effusions help to differentiate between the 2?
Journal article   Peer reviewed

Transudate or exudate: can lactate dehydrogenase activity in canine and feline effusions help to differentiate between the 2?

C.M. Smuts, J.N. Mills and T. Gaál
Veterinary Clinical Pathology, Vol.45(4), pp.680-688
2016
DOI: https://doi.org/10.1111/vcp.12397
url
Link to Published Version *Subscription may be requiredView

Abstract

Background: Lactate dehydrogenase (LDH) activity is often measured in human effusions to help in differentiating between transudates and exudates. Few studies have been performed using effusion samples from animals. Objectives: The purpose of the study was to determine whether LDH can be used to differentiate between transudative and exudative effusions in dogs and cats (including postmortem samples), and whether there is a difference between different laboratory methods of LDH measurement. Methods: Lactate dehydrogenase activity was measured in canine and feline effusions that were submitted to the Murdoch University Veterinary Hospital Clinical Pathology Laboratory over approximately 12 months using 2 wet and one dry chemistry methods, including 10 effusions collected postmortem. Results were compared to classification using traditional methods for effusion types. Results: Lactate dehydrogenase activity was significantly higher in exudates than in transudates, significantly different depending on the method of measurement, and significantly higher in all effusions collected postmortem. An LDH effusion:serum ratio of < 0.5 was associated with transudates. There was no significant difference between samples collected into EDTA or plain serum tubes, in frozen and thawed samples, or after storage at 4°C for 3-7 days. Conclusions: Measurement of LDH activity may be useful in helping to differentiate between transudates and exudates in cats and dogs. The method of measurement must be known and kept consistent if cutoff values are to be used. The LDH activity was increased in all effusions collected from animals after death, potentially invalidating its use postmortem.

Details

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

Source: InCites

Metrics

66 Record Views
11 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Citation topics
1 Clinical & Life Sciences
1.199 Lung Cancer
1.199.1048 Pulmonary Ultrasound
Web Of Science research areas
Veterinary Sciences
ESI research areas
Plant & Animal Science
Logo image