Journal article
Traveling the vitamin B12 pathway: Oral delivery of protein and peptide drugs
Angewandte Chemie International Edition, Vol.48(6), pp.1022-1028
2009
Abstract
Oral routes of administration for therapeutic peptides and proteins face two major barriers: proteolytic degradation in the stomach and an inadequate absorption mechanism for polypeptides within the intestinal lumen. As a result, peptide-based therapeutics are administered by injection, a painful process associated with lower patient compliance. The development of a means of overcoming these two major obstacles and enabling the successful delivery of peptide therapeutics by the oral route of administration has therefore been the target of extensive scientific endeavor. This Minireview focuses on oral peptide/ protein delivery by the dietary uptake pathway for vitamin B 12. Recent progress in this field includes the delivery of erythropoietin, granulocyte-colony-stimulating factor, luteinizing-hormone- releasing hormone, and insulin.
Details
- Title
- Traveling the vitamin B12 pathway: Oral delivery of protein and peptide drugs
- Authors/Creators
- A.K. Petrus (Author/Creator) - Syracuse UniversityT.J. Fairchild (Author/Creator) - Syracuse UniversityR.P. Doyle (Author/Creator) - Syracuse University
- Publication Details
- Angewandte Chemie International Edition, Vol.48(6), pp.1022-1028
- Publisher
- John Wiley & Sons Ltd
- Identifiers
- 991005544100607891
- Copyright
- © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 2 Chemistry
- 2.276 Metalloenzymes
- 2.276.1947 Radical Enzymes
- Web Of Science research areas
- Chemistry, Multidisciplinary
- ESI research areas
- Chemistry