Trends in detectable viral load by calendar year in the Australian HIV observational database

M.G. Law; I. Woolley; D.J. Templeton; N. Roth; J. Chuah; B. Mulhall; P. Canavan; H. McManus; D.A. Cooper; K. Petoumenos; D. Nolan

doi:10.1186/1758-2652-14-10

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Trends in detectable viral load by calendar year in the Australian HIV observational database

Journal article

Open access

Peer reviewed

Trends in detectable viral load by calendar year in the Australian HIV observational database

M.G. Law, I. Woolley, D.J. Templeton, N. Roth, J. Chuah, B. Mulhall, P. Canavan, H. McManus, D.A. Cooper, K. Petoumenos, …

Journal of the International AIDS Society, Vol.14(1), pp.10-16

2011

DOI: https://doi.org/10.1186/1758-2652-14-10

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Abstract

Background Recent papers have suggested that expanded combination antiretroviral treatment (cART) through lower viral load may be a strategy to reduce HIV transmission at a population level. We assessed calendar trends in detectable viral load in patients recruited to the Australian HIV Observational Database who were receiving cART. Methods Patients were included in analyses if they had started cART (defined as three or more antiretrovirals) and had at least one viral load assessment after 1 January 1997. We analyzed detectable viral load (>400 copies/ml) in the first and second six months of each calendar year while receiving cART. Repeated measures logistic regression methods were used to account for within and between patient variability. Rates of detectable viral load were predicted allowing for patients lost to follow up. Results Analyses were based on 2439 patients and 31,339 viral load assessments between 1 January 1997 and 31 March 2009. Observed detectable viral load in patients receiving cART declined to 5.3% in the first half of 2009. Predicted detectable viral load based on multivariate models, allowing for patient loss to follow up, also declined over time, but at higher levels, to 13.8% in 2009. Conclusions Predicted detectable viral load in Australian HIV Observational Database patients receiving cART declined over calendar time, albeit at higher levels than observed. However, over this period, HIV diagnoses and estimated HIV incidence increased in Australia.

Details

Title: Trends in detectable viral load by calendar year in the Australian HIV observational database
Authors/Creators: M.G. Law (Author/Creator) - UNSW Sydney
I. Woolley (Author/Creator) - Monash Medical Centre
D.J. Templeton (Author/Creator) - UNSW Sydney
N. Roth (Author/Creator) - Prahran Market Clinic, Prahran, Australia
J. Chuah (Author/Creator) - Sexual Health Clinic
B. Mulhall (Author/Creator) - The University of Sydney
P. Canavan (Author/Creator) - National Association of People with HIV Australia
H. McManus (Author/Creator) - UNSW Sydney
D.A. Cooper (Author/Creator) - UNSW Sydney
K. Petoumenos (Author/Creator) - UNSW Sydney
D. Nolan (Author/Creator)
Publication Details: Journal of the International AIDS Society, Vol.14(1), pp.10-16
Publisher: BioMed Central
Identifiers: 991005542547707891
Copyright: 2011 Law et al.
Murdoch Affiliation: Institute for Immunology and Infectious Diseases
Language: English
Resource Type: Journal article
Note: David Nolan appears on Behalf of the Australian HIV Observational Database (AHOD)

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.66 HIV; 1.66.11 HIV/AIDS Prevention
Web Of Science research areas: Immunology; Infectious Diseases
ESI research areas: Immunology