Journal article
Specificity and sensitivity of serum canine pancreatic elastase-1 concentration in the diagnosis of pancreatitis
Journal of Veterinary Diagnostic Investigation, Vol.23(4), pp.691-697
2011
Abstract
The aim of the current study was to determine the sensitivity and specificity of serum canine pancreatic elastase-1 (cPE-1) for the diagnosis of pancreatitis in dogs. The study was prospective, assessing dogs presenting with clinical signs similar to pancreatitis. Sixty-one dogs were recruited (49 with pancreatic disease and 12 with non-pancreatic disease). There was no significant difference in serum cPE-1 between dogs with pancreatic disease and non-pancreatic disease. However, there was a significant difference in serum cPE-1 between severe acute pancreatitis and non-pancreatic disease. A cut-off value for serum cPE-1 > 17.24 ng/ml resulted in sensitivity of 61.4% and specificity of 91.7% for diagnosis of all types of pancreatic disease. The sensitivity rose to 65.85% and 78.26% for the diagnosis of all types of acute pancreatitis and severe acute pancreatitis, respectively. Serum cPE-1 is more sensitive at diagnosing severe acute pancreatitis than chronic or mild acute pancreatitis, and has a high positive likelihood ratio. Dogs with chronic pancreatitis tended to have lower serum cPE-1 concentration, suggesting decreased exocrine function.
Details
- Title
- Specificity and sensitivity of serum canine pancreatic elastase-1 concentration in the diagnosis of pancreatitis
- Authors/Creators
- C.S. Mansfield (Author/Creator) - Murdoch UniversityP.D. Watson (Author/Creator) - University College DublinB.R. Jones (Author/Creator) - University College Dublin
- Publication Details
- Journal of Veterinary Diagnostic Investigation, Vol.23(4), pp.691-697
- Publisher
- American Association of Veterinary Laboratory Diagnosticians
- Identifiers
- 991005542258207891
- Copyright
- © 2011 The Author(s)
- Murdoch Affiliation
- School of Veterinary and Biomedical Sciences
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.151 Pancreas & Gall Bladder Disorders
- 1.151.676 Pancreatitis
- Web Of Science research areas
- Veterinary Sciences
- ESI research areas
- Plant & Animal Science