Journal article
Trilostane treatment in dogs with pituitary-dependent hyperadreno-corticism
Australian Veterinary Journal, Vol.81(10), pp.600-607
2003
Abstract
Objective
To evaluate the efficacy of trilostane in treating dogs with pituitary-dependent hyperadrenocorticism.
Design
Prospective clinical trial using client-owned dogs with pituitary-dependent hyperadrenocorticism treated at University Veterinary Centre, Sydney from September 1999 to July 2001.
Procedure
Thirty dogs with pituitary-dependent hyperadrenocorticism treated with trilostane, a competitive inhibitor β-HSD, were monitored at days 10, 30 and 90 then 3-monthly by clinical examination, tetracosactrin stimulation testing, urinary corticoid:creatinine ratio measurement and by client questionnaire.
Results
Twenty-nine of 30 dogs were successfully treated with trilostane (median dose 16.7 mg/kg; range 5.3 to 50 mg/kg, administered once daily); one responded favourably but died of unrelated disease before full control was achieved.
Conclusion
Trilostane administration controlled pituitary-dependent hyperadrenocorticism in these dogs. It was safe, effective and free of side-effects at the doses used. Most dogs were initially quite sensitive to the drug for 10 to 30 days, then required higher doses until a prolonged phase of stable dose requirements occurred. Urinary corticoid:creatinine ratio was useful in assessing duration of drug effect. Some dogs treated for more than 2 years required reduction or temporary cessation of drug because of iatrogenic hypoadrenocorticism.
Details
- Title
- Trilostane treatment in dogs with pituitary-dependent hyperadreno-corticism
- Authors/Creators
- J.A. Braddock (Author/Creator) - The University of SydneyD.B. Church (Author/Creator) - Royal Veterinary CollegeI.D. Robertson (Author/Creator) - Murdoch UniversityA.D.J. Watson (Author/Creator) - The University of Sydney
- Publication Details
- Australian Veterinary Journal, Vol.81(10), pp.600-607
- Publisher
- Wiley-Blackwell
- Identifiers
- 991005540321907891
- Murdoch Affiliation
- School of Veterinary and Biomedical Sciences
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Metrics
64 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- International collaboration
- Citation topics
- 3 Agriculture, Environment & Ecology
- 3.232 Veterinary Sciences
- 3.232.1281 Veterinary Reproductive Health
- Web Of Science research areas
- Veterinary Sciences
- ESI research areas
- Plant & Animal Science