Tumour necrosis factor-alpha gene -238G/A promoter polymorphism associated with a more rapid onset of lipodystrophy

D. Nolan; C. Moore; A. Castley; D. Sayer; C. Marmotte; M. John; I. James; S. Mallal

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Tumour necrosis factor-alpha gene -238G/A promoter polymorphism associated with a more rapid onset of lipodystrophy

Journal article

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Tumour necrosis factor-alpha gene -238G/A promoter polymorphism associated with a more rapid onset of lipodystrophy

D. Nolan, C. Moore, A. Castley, D. Sayer, C. Marmotte, M. John, I. James and S. Mallal

AIDS, Vol.17(1), pp.121-123

2003

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Abstract

The effect of TNF polymorphisms on the time-to-onset of lipodystrophy was investigated in 191 Caucasian participants in the western Australian HIV cohort. Carriage of the TNF-α-238G/A polymorphism was found in 13.1% of the cohort, and was associated with an earlier onset of lipodystrophy. The presence of TNF-α-238G/A was associated with lipodystrophy progression in Cox proportional hazards regression analyses, without influencing the relative risk and significance of other predictive host and treatment-related variables.

Details

Title: Tumour necrosis factor-alpha gene -238G/A promoter polymorphism associated with a more rapid onset of lipodystrophy
Authors/Creators: D. Nolan (Author/Creator)
C. Moore (Author/Creator)
A. Castley (Author/Creator)
D. Sayer (Author/Creator)
C. Marmotte (Author/Creator)
M. John (Author/Creator)
I. James (Author/Creator)
S. Mallal (Author/Creator)
Publication Details: AIDS, Vol.17(1), pp.121-123
Publisher: Lippincott Williams & Wilkins Ltd.
Identifiers: 991005540653007891
Murdoch Affiliation: Centre for Clinical Immunology and Biomedical Statistics
Language: English
Resource Type: Journal article

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