Journal article
Type I IFN-beta gene therapy suppresses cardiac CD8+ T-cell infiltration during autoimmune myocarditis
Immunology and Cell Biology, Vol.82(2), pp.119-126
2004
Abstract
Gene therapy using DNA encoding type I IFN subtypes IFNA6, IFNA9 and IFNB suppresses murine cytomegalovirus (MCMV)-myocarditis, a predominantly cell-mediated disease in BALB/c mice. CD8+ T cells are the principal cell type within the inflamed myocardium. As such, we investigated the effects of IFN subtype treatment on this T-cell subset and other cell types in the cardiac infiltrate. In the acute phase of disease, IFNA6 and IFNA9 treatments significantly reduced the number of CD8+ T cells within the foci of cellular infiltration in the heart. During the chronic phase, which is primarily autoimmune in nature, IFNB treatment significantly reduced CD8+ T cells. B-cell and neutrophil numbers in the cardiac infiltrate were also reduced following IFNB immunotherapy. Although early inflammatory responses are important for resolution of virus infection, high numbers of lymphocytes persisting in the myocardium may lead to exacerbation of disease. Our data suggests that type I IFN DNA therapy regulates cardiac cellular infiltration. Thus, treatment with IFN-β administered prophylactically to high-risk patients in acquiring CMV infection may reduce the development of chronic autoimmune myocarditis.
Details
- Title
- Type I IFN-beta gene therapy suppresses cardiac CD8+ T-cell infiltration during autoimmune myocarditis
- Authors/Creators
- E.J. Bartlett (Author/Creator) - Murdoch UniversityJ.C. Lenzo (Author/Creator) - Murdoch UniversityS. Sivamoorthy (Author/Creator) - Murdoch UniversityJ.P. Mansfield (Author/Creator) - Murdoch UniversityV.S. Cull (Author/Creator) - Murdoch UniversityC.M. James (Author/Creator) - Murdoch University
- Publication Details
- Immunology and Cell Biology, Vol.82(2), pp.119-126
- Publisher
- Nature Publishing Group
- Identifiers
- 991005545006007891
- Murdoch Affiliation
- School of Veterinary and Biomedical Sciences
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 1 Clinical & Life Sciences
- 1.37 Cardiology - General
- 1.37.1920 Myocarditis
- Web Of Science research areas
- Cell Biology
- Immunology
- ESI research areas
- Immunology