Unveiling the Bioactive Compounds and Therapeutic Potential of Russula: A Comprehensive Review

Jingya Yang; Samantha C. Karunarathna; Nimesha Patabendige; Entaj Tarafder; Dengji Lou; Yuanqing Zhou; Kalani Hapuarachchi

doi:10.3390/jof11050341

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Unveiling the Bioactive Compounds and Therapeutic Potential of Russula: A Comprehensive Review

Journal article

Open access

Peer reviewed

Unveiling the Bioactive Compounds and Therapeutic Potential of Russula: A Comprehensive Review

Jingya Yang, Samantha C. Karunarathna, Nimesha Patabendige, Entaj Tarafder, Dengji Lou, Yuanqing Zhou and Kalani Hapuarachchi

Journal of fungi (Basel), Vol.11(5), 341

2025

DOI: https://doi.org/10.3390/jof11050341

PMID: 40422676

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Abstract

Review

Russula, a genus of Basidiomycetes with considerable taxonomic diversity, holds significant potential in both traditional and modern medicinal practices. This comprehensive review explores the bioactive compounds identified in various Russula species, detailing their characterization, structural elucidation, and classification. The medicinal properties of these fungi are examined, with a focus on their antioxidant, anti-inflammatory, and immunomodulatory effects, supported by both historical usage and contemporary preclinical pharmacological research. The review also highlights emerging biotechnological applications including environmental remediation, antimicrobial agents, and functional food development. Safety and toxicological considerations are evaluated to provide a balanced perspective on the medicinal use of Russula. The review concludes by summarizing the key findings and emphasizing the importance of Russula in both traditional medicine and future clinically validated innovations.

Details

Title: Unveiling the Bioactive Compounds and Therapeutic Potential of Russula: A Comprehensive Review
Authors/Creators: Jingya Yang - Yuxi Normal University
Samantha C. Karunarathna - Qujing Normal University
Nimesha Patabendige - Murdoch University
Entaj Tarafder - Guizhou University
Dengji Lou - Yuxi Normal University
Yuanqing Zhou - Yuxi Normal University
Kalani Hapuarachchi - Southwest Forestry University
Publication Details: Journal of fungi (Basel), Vol.11(5), 341
Publisher: MDPI
Number of pages: 46
Grant note: 202401CF070040 / Yunnan Fundamental Research Project 2023J0993 / Yunnan Department of Education Scientific Research Fund Project
Identifiers: 991005779512907891
Copyright: © 2025 by the authors.
Murdoch Affiliation: School of Medical, Molecular and Forensic Sciences
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration; International collaboration
Citation topics: 3 Agriculture, Environment & Ecology; 3.16 Phytochemicals; 3.16.2318 Silymarin
Web Of Science research areas: Microbiology; Mycology
ESI research areas: Plant & Animal Science