Journal article
Up-Regulation of cutaneous α1-Adrenoceptors in complex regional pain syndrome Type I
Pain Medicine, Vol.15(11), pp.1945-1956
2014
Abstract
Background
In a small radioligand-binding study of cutaneous α1-adrenoceptors in complex regional pain syndrome (CRPS), signal intensity was greater in the CRPS-affected limb than in controls. However, it was not possible to localize heightened expression of α1-adrenoceptors to nerves, sweat glands, blood vessels, or keratinocytes using this technique.
Methods
To explore this in the present study, skin biopsies were obtained from 31 patients with CRPS type I and 23 healthy controls of similar age and sex distribution. Expression of α1-adrenoceptors on keratinocytes and on dermal blood vessels, sweat glands, and nerves was assessed using immunohistochemistry.
Results
α1-Adrenoceptors were expressed more strongly in dermal nerve bundles and the epidermis both on the affected and contralateral unaffected side in patients than in controls (P < 0.05). However, expression of α1-adrenoceptors in sweat glands and blood vessels was similar in patients and controls. α1-Adrenoceptor staining intensity in the CRPS-affected epidermis was associated with pain intensity (P < 0.05), but a similar trend for nerve bundles did not achieve statistical significance.
Discussion
Epidermal cells influence nociception by releasing ligands that act on sensory nerve fibers. Moreover, an increased expression of α1-adrenoceptors on nociceptive afferents has been shown to aggravate neuropathic pain. Thus, the heightened expression of α1-adrenoceptors in dermal nerves and epidermal cells might augment pain and neuroinflammatory disturbances after tissue injury in patients with CRPS type I.
Details
- Title
- Up-Regulation of cutaneous α1-Adrenoceptors in complex regional pain syndrome Type I
- Authors/Creators
- P.M. Finch (Author/Creator) - Murdoch UniversityE.S. Drummond (Author/Creator) - Murdoch UniversityL.F. Dawson (Author/Creator) - Murdoch UniversityJ.K. Phillips (Author/Creator) - Australian School of Advanced MedicineP.D. Drummond (Author/Creator) - Murdoch University
- Publication Details
- Pain Medicine, Vol.15(11), pp.1945-1956
- Publisher
- Wiley
- Identifiers
- 991005540322807891
- Copyright
- 2014 Wiley Periodicals, Inc
- Murdoch Affiliation
- School of Psychology and Exercise Science
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.43 Anesthesiology
- 1.43.1905 Complex Regional Pain Syndrome
- Web Of Science research areas
- Anesthesiology
- ESI research areas
- Clinical Medicine