Journal article
Update on genomic and molecular landscapes of well-differentiated liposarcoma and dedifferentiated liposarcoma
Molecular Biology Reports
2021
Abstract
Well-differentiated liposarcoma (WDLPS) is the most frequent subtype of liposarcoma and may transform into dedifferentiated liposarcoma (DDLPS) which is a more aggressive subtype. Retroperitoneal lesions of WDLPS/DDLPS tend to recur repeatedly due to incomplete resections, and adjuvant chemotherapy and radiotherapy have little effect on patient survival. Consequently, identifying therapeutic targets and developing targeted drugs is critical for improving the outcome of WDLPS/DDLPS patients. In this review, we summarised the mutational landscape of WDLPS/DDLPS from recent studies focusing on potential oncogenic drivers and the development of molecular targeted drugs for DDLPS. Due to the limited number of studies on the molecular networks driving WDLPS to DDLPS development, we looked at other dedifferentiation-related tumours to identify potential parallel mechanisms that could be involved in the dedifferentiation process generating DDLPS.
Details
- Title
- Update on genomic and molecular landscapes of well-differentiated liposarcoma and dedifferentiated liposarcoma
- Authors/Creators
- J. Lu (Author/Creator) - The University of Western AustraliaD. Wood (Author/Creator) - The University of Western AustraliaE. Ingley (Author/Creator) - Harry Perkins Institute of Medical ResearchS. Kõks (Author/Creator) - Perron Institute for Neurological and Translational ScienceD. Wong (Author/Creator) - Pathwest Laboratory Medicine
- Publication Details
- Molecular Biology Reports
- Publisher
- Springer Netherlands
- Identifiers
- 991005542092007891
- Copyright
- © 2021 Springer Nature Switzerland AG.
- Murdoch Affiliation
- Centre for Molecular Medicine and Innovative Therapeutics
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.118 Soft Tissue, Bone & Nerve Cancers
- 1.118.300 Sarcoma Research
- Web Of Science research areas
- Biochemistry & Molecular Biology
- ESI research areas
- Molecular Biology & Genetics