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Update on toxic myopathies
Journal article   Peer reviewed

Update on toxic myopathies

F.L. Mastaglia and M. Needham
Current Neurology and Neuroscience Reports, Vol.12(1), pp.54-61
2012
DOI: https://doi.org/10.1007/s11910-011-0232-9
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Abstract

The toxic myopathies are a clinically and pathologically diverse group of disorders that can be caused by a variety of therapeutic agents used in clinical practice, as well as various venoms and other biological toxins. The most important iatrogenic causes are the statin and fibrate cholesterol-lowering agents that can cause a severe necrotizing myopathy and acute rhabdomyolysis and myoglobinuria. The current update focuses on the mechanisms of statin myotoxicity and the importance of genetic predisposing factors for statin myopathy, as well as the recently described form of necrotizing autoimmune myopathy, which is associated with antibodies to the 3-hydroxy-3-methylglutaryl-coenzyme A reductase enzyme and is responsive to aggressive immunotherapy. Mitochondrial myopathies associated with antiretroviral agents and the pyrimidine nucleoside analogue clevudine, and recent reports of myopathies caused by ingestion of red yeast rice and toxic species of mushrooms are also discussed.

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UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

Source: InCites

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17 Record Views
44 Times Cited - Web of Science

InCites Highlights

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Collaboration types
Domestic collaboration
Citation topics
1 Clinical & Life Sciences
1.68 Lipids
1.68.236 Statins and Cardiovascular Health
Web Of Science research areas
Clinical Neurology
Neurosciences
ESI research areas
Neuroscience & Behavior
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