Journal article
Upper body accelerations as a biomarker of gait impairment in the early stages of Parkinson’s disease
Gait and Posture, Vol.71, pp.289-295
2019
Abstract
Background
Changes in upper body (UB) motion during gait may be a marker of incipient pathology, intervention response and disease progression in Parkinson’s disease (PD), which if independent from the lower body motion, might provide an improved assessment of gait.
Research question
This study aimed to test this hypothesis and establish whether variables calculated from accelerations measured on the UB are unique from spatiotemporal characteristics and can contribute to an improved classification of PD gait.
Methods
Data was obtained from 70 people with PD (69.2 ± 9.9 y.o., UPDRS III: 36.9 ± 12.3) and 64 age-matched controls (71.6 ± 6.8 y.o.). Spatiotemporal characteristics were measured using a pressure sensitive mat (GAITRite). Head and pelvis accelerations were synchronously measured with wearable inertial sensors (Opal, APDM). Pearson’s product-moment correlations were calculated between 49 selected variables from UB accelerations (representing magnitude, smoothness, regularity, symmetry and attenuation) and 16 traditional spatiotemporal characteristics (representing pace, variability, rhythm, asymmetry and postural control). Univariate and multivariate regression analysis was used to test the variables ability to classify PD gait.
Results
The variables were mostly unique from each other (67% of variables recorded an r < 0.3). Univariate and multivariate analysis showed that UB variables were moderately better at classifying PD gait than the spatiotemporal characteristics (Univariate: 0.70 to 0.81, Multivariate: 0.88 to 0.91 AUC).
Significance
This study showed for the first time that, if aiming at objective and optimal sensitive biomarkers for PD, UB variables should be measured in conjunction with spatiotemporal characteristics to obtain a more holistic assessment of PD gait for use in a clinical or free-living environment.
Details
- Title
- Upper body accelerations as a biomarker of gait impairment in the early stages of Parkinson’s disease
- Authors/Creators
- C. Buckley (Author/Creator) - Arthritis Research UKB. Galna (Author/Creator) - Institute of Neuroscience/Newcastle University Institute for Ageing, Newcastle University, Clinical Ageing Research Unit, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UKL. Rochester (Author/Creator) - Newcastle UniversityC. Mazzà (Author/Creator) - Arthritis Research UK
- Publication Details
- Gait and Posture, Vol.71, pp.289-295
- Publisher
- Elsevier B.V.
- Identifiers
- 991005540361407891
- Copyright
- © 2018
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Metrics
23 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.82 Gait & Posture
- 1.82.263 Gait and Balance
- Web Of Science research areas
- Neurosciences
- Orthopedics
- Sport Sciences
- ESI research areas
- Clinical Medicine