Urinary oxygen tension: A clinical window on the health of the renal medulla?

R.G. Evans; J.A. Smith; C. Wright; B.S. Gardiner; D.W. Smith; A.D. Cochrane

doi:10.1152/ajpregu.00437.2013

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Urinary oxygen tension: A clinical window on the health of the renal medulla?

Journal article

Peer reviewed

Urinary oxygen tension: A clinical window on the health of the renal medulla?

R.G. Evans, J.A. Smith, C. Wright, B.S. Gardiner, D.W. Smith and A.D. Cochrane

AJP: Regulatory, Integrative and Comparative Physiology, Vol.306(1), pp.R45-R50

2014

DOI: https://doi.org/10.1152/ajpregu.00437.2013

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Abstract

We describe the determinants of urinary oxygen tension (Po2) and the potential for use of urinary PO2 as a "physiological biomarker" of the risk of acute kidney injury (AKI) in hospital settings. We also identify knowledge gaps required for clinical translation of bedside monitoring of urinary PO2. Hypoxia in the renal medulla is a hallmark of AKI of diverse etiology. Urine in the collecting ducts would be expected to equilibrate with the tissue PO2 of the inner medulla. Accordingly, the PO2 of urine in the renal pelvis changes in response to stimuli that would be expected to alter oxygenation of the renal medulla. Oxygen exchange across the walls of the ureter and bladder will confound measurement of the PO2 of bladder urine. Nevertheless, the PO2 of bladder urine also changes in response to stimuli that would be expected to alter renal medullary oxygenation. If confounding influences can be understood, urinary bladder PO2 may provide prognostically useful information, including for prediction of AKI after cardiopulmonary bypass surgery. To translate bedside monitoring of urinary PO2 into the clinical setting, we require 1) a more detailed knowledge of the relationship between renal medullary oxygenation and the PO2 of pelvic urine under physiological and pathophysiological conditions; 2) a quantitative understanding of the impact of oxygen transport across the ureteric epithelium on urinary PO2 measured from the bladder; and 3) a simple, robust medical device that can be introduced into the bladder via a standard catheter to provide reliable and continuous measurement of urinary PO2.

Details

Title: Urinary oxygen tension: A clinical window on the health of the renal medulla?
Authors/Creators: R.G. Evans (Author/Creator) - Department of Physiology.
J.A. Smith (Author/Creator) - Monash Medical Centre
C. Wright (Author/Creator) - Monash University
B.S. Gardiner (Author/Creator) - The University of Western Australia
D.W. Smith (Author/Creator) - The University of Western Australia
A.D. Cochrane (Author/Creator) - Monash Medical Centre
Publication Details: AJP: Regulatory, Integrative and Comparative Physiology, Vol.306(1), pp.R45-R50
Publisher: American Physiological Society
Identifiers: 991005540268807891
Copyright: © 2014 the American Physiological Society.
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

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Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.55 Urology & Nephrology - General; 1.55.830 Acute Kidney Injury
Web Of Science research areas: Physiology
ESI research areas: Biology & Biochemistry