Use of a tetanus toxoid marker to allow differentiation of infected from vaccinated poultry without affecting the efficacy of a H5N1 avian influenza virus vaccine

C.M. James-Berry; D. Middleton; J.P. Mansfield; S.G. Fenwick; T.M. Ellis

doi:10.1136/vr.c5798

Back

Use of a tetanus toxoid marker to allow differentiation of infected from vaccinated poultry without affecting the efficacy of a H5N1 avian influenza virus vaccine

Journal article

Open access

Peer reviewed

Use of a tetanus toxoid marker to allow differentiation of infected from vaccinated poultry without affecting the efficacy of a H5N1 avian influenza virus vaccine

C.M. James-Berry, D. Middleton, J.P. Mansfield, S.G. Fenwick and T.M. Ellis

Veterinary Record, Vol.167(18), pp.695-699

2010

DOI: https://doi.org/10.1136/vr.c5798

Files and links (2)

pdf

tetanus_toxoid_marker.pdfDownload View

Published (Version of Record) Open Access

url

Link to Published Version *Subscription may be requiredView

Abstract

Tetanus toxoid (TT) was assessed as a positive marker for avian influenza (AI) virus vaccination in chickens, in a vaccination and challenge study. Chickens were vaccinated twice with inactivated AI H5N2 virus vaccine, and then challenged three weeks later with highly pathogenic AI H5N1 virus. Vaccinated chickens were compared with other groups that were either sham-vaccinated or vaccinated with virus with the TT marker. All sham-vaccinated chickens died by 36 hours postinfection, whereas all vaccinated chickens, with or without the TT marker, were protected from morbidity and mortality following exposure to the challenge virus. Serological testing for H5-specific antibodies identified anamnestic responses to H5 in some of the vaccinated birds, indicating active virus infection.

Details

Title: Use of a tetanus toxoid marker to allow differentiation of infected from vaccinated poultry without affecting the efficacy of a H5N1 avian influenza virus vaccine
Authors/Creators: C.M. James-Berry (Author/Creator)
D. Middleton (Author/Creator)
J.P. Mansfield (Author/Creator)
S.G. Fenwick (Author/Creator)
T.M. Ellis (Author/Creator)
Publication Details: Veterinary Record, Vol.167(18), pp.695-699
Publisher: British Veterinary Association
Identifiers: 991005540180607891
Murdoch Affiliation: School of Veterinary and Biomedical Sciences
Language: English
Resource Type: Journal article

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites

Metrics

243 File views/ downloads

67 Record Views

2 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration
Citation topics: 1 Clinical & Life Sciences; 1.104 Virology - General; 1.104.126 Influenza
Web Of Science research areas: Veterinary Sciences
ESI research areas: Plant & Animal Science