Journal article
Use of remifentanil as a sedative agent in critically ill adult patients: a meta-analysis
Anaesthesia, Vol.64(12), pp.1342-1352
2009
Abstract
This meta-analysis examined the benefits of using remifentanil as a sedative agent in critically ill patients. A total of 11 randomised controlled trials, comparing remifentanil with another opioid or hypnotic agent in 1067 critically ill adult patients, were identified from the Cochrane controlled trials register and EMBASE and MEDLINE databases, and subjected to meta-analysis. Remifentanil was associated with a reduction in the time to tracheal extubation after cessation of sedation (weighted-mean-difference -2.04 h (95% CI -0.39 to -3.69 h); p = 0.02). Remifentanil was, however, not associated with a significant reduction in mortality (relative risk 1.01 -95% CI 0.67-1.52); p = 0.96), duration of mechanical ventilation, length of intensive care unit stay, and risk of agitation (relative risk 1.08 (95% CI 0.64-1.82); p = 0.77) when compared to an alternative sedative or analgesic agent. The current evidence does not support the routine use of remifentanil as a sedative agent in critically ill adult patients.
Details
- Title
- Use of remifentanil as a sedative agent in critically ill adult patients: a meta-analysis
- Authors/Creators
- J.A. Tan (Author/Creator) - Marymount UniversityK.M. Ho (Author/Creator) - The University of Western Australia
- Publication Details
- Anaesthesia, Vol.64(12), pp.1342-1352
- Publisher
- Wiley
- Identifiers
- 991005543665207891
- Copyright
- © 2009 The Authors
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.154 Assisted Ventilation
- 1.154.1403 Delirium
- Web Of Science research areas
- Anesthesiology
- ESI research areas
- Clinical Medicine