Journal article
Validation of a priori candidate Alzheimer’s disease SNPs with brain amyloid-beta deposition
Scientific Reports, Vol.9(1), Art. 17069
2019
Abstract
The accumulation of brain amyloid β (Aβ) is one of the main pathological hallmarks of Alzheimer’s disease (AD). However, the role of brain amyloid deposition in the development of AD and the genetic variants associated with this process remain unclear. In this study, we sought to identify associations between Aβ deposition and an a priori evidence based set of 1610 genetic markers, genotyped from 505 unrelated individuals (258 Aβ+ and 247 Aβ−) enrolled in the Australian Imaging, Biomarker & Lifestyle (AIBL) study. We found statistically significant associations for 6 markers located within intronic regions of 6 genes, including AC103796.1-BDNF, PPP3R1, NGFR, KL, ABCA7 & CALHM1. Although functional studies are required to elucidate the role of these genes in the accumulation of Aβ and their potential implication in AD pathophysiology, our findings are consistent with results obtained in previous GWAS efforts.
Details
- Title
- Validation of a priori candidate Alzheimer’s disease SNPs with brain amyloid-beta deposition
- Authors/Creators
- M. Vacher (Author/Creator)T. Porter (Author/Creator)V.L. Villemagne (Author/Creator)L. Milicic (Author/Creator)M. Peretti (Author/Creator)C. Fowler (Author/Creator)R. Martins (Author/Creator)S. Rainey-Smith (Author/Creator)D. Ames (Author/Creator)C.L. Masters (Author/Creator)C.C. Rowe (Author/Creator)J.D. Doecke (Author/Creator)S.M. Laws (Author/Creator)
- Publication Details
- Scientific Reports, Vol.9(1), Art. 17069
- Publisher
- Springer Nature
- Identifiers
- 991005545151707891
- Copyright
- © 2021 Springer Nature Limited
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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Source: InCites
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- Collaboration types
- Domestic collaboration
- Citation topics
- 1 Clinical & Life Sciences
- 1.52 Neurodegenerative Diseases
- 1.52.57 Alzheimer's Mechanisms
- Web Of Science research areas
- Neurosciences
- ESI research areas
- Neuroscience & Behavior