Journal article
Validity of minimal clinically important difference values for the Multiple Sclerosis walking Scale-12?
European Neurology, Vol.71(3-4), pp.196-202
2014
Abstract
Background and Objective: Minimal clinically important difference (MCID) values of 4 and 6 points have been proposed for interpreting meaningful change in Multiple Sclerosis Walking Scale-12 (MSWS-12) scores. This study examined the validity of those MCID values based on capturing corresponding changes in other walking outcomes in persons with multiple sclerosis (MS). Methods: On 2 occasions separated by 6 months, 82 persons with MS completed the MSWS-12, timed 25-ft walk (T25FW), 6-min walk (6MW), and gait analysis, and then wore an accelerometer over a 7-day period. We generated change scores for the MSWS-12 and formed groups of stable, worsened, and improved perceived walking based on both 4- and 6-point changes. The groups were compared for corresponding changes in other walking measures over time using mixed-model ANOVAs. Results: The mixed-model ANOVAs did not identify statistically significant group-by-time interactions on the T25FW (p = 0.98 and p = 0.67), the 6MW (p = 0.89 and p = 0.72), gait (p = 0.54 and p = 0.21), or accelerometry (p = 0.40 and p = 0.68) for MCID values of 4- or 6-point changes in MSWS-12 scores. Conclusions: We did not confirm that MCID values of 4 and 6 points for the MSWS-12 correspond with changes in performance, gait, and free-living assessments of walking in MS.
Details
- Title
- Validity of minimal clinically important difference values for the Multiple Sclerosis walking Scale-12?
- Authors/Creators
- R.W. Motl (Author/Creator) - University of Illinois Urbana-ChampaignY.C. Learmonth (Author/Creator) - University of Illinois Urbana-ChampaignL.A. Pilutti (Author/Creator) - Kinesiology and Community HealthD. Dlugonski (Author/Creator) - University of Illinois Urbana-ChampaignR. Klaren (Author/Creator) - University of Illinois Urbana-Champaign
- Publication Details
- European Neurology, Vol.71(3-4), pp.196-202
- Publisher
- Karger
- Identifiers
- 991005540051607891
- Copyright
- © 2014 S. Karger AG, Basel
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 1 Clinical & Life Sciences
- 1.203 Neuromuscular Disorders
- 1.203.147 Multiple Sclerosis
- Web Of Science research areas
- Clinical Neurology
- Neurosciences
- ESI research areas
- Neuroscience & Behavior