Journal article
Valproate modulates glucose metabolism in patients with epilepsy after first exposure
Epilepsia, Vol.56(11), pp.e172-e175
2015
Abstract
Valproate (VPA) treatment has been reported to be associated with weight gain and metabolic changes, such as hyperinsulinemia. The question of whether hyperinsulinemia and other metabolic changes are consequences of increased weight, or are instead direct results of VPA treatment, remains a matter of debate. The aim of the current study was to explore the influence of VPA treatment on glucose and insulin levels during the oral glucose tolerance test (OGTT) directly following the first intravenous (IV) administration. Sixteen patients (18–46 years old) with newly diagnosed epilepsy underwent an OGTT with 75 g glucose prior to the start of VPA treatment, as well as directly following the first IV VPA administration. We observed that plasma glucose levels during the 120 min of OGTT session following infusion of VPA were significantly lower than those measured during OGTT without VPA treatment (mean ± standard deviation [SD] 4.28 ± 0.94 mmol/l vs. 4.75 ± 1.09 mmol/l respectively, p = 0.038). However, blood concentrations of insulin and C‐peptide did not differ significantly between the two measurements. This is the first study to show a potential acute glucose‐lowering effect of VPA during OGTT in patients with newly diagnosed epilepsy.
Details
- Title
- Valproate modulates glucose metabolism in patients with epilepsy after first exposure
- Authors/Creators
- A. Rakitin (Author/Creator) - University of TartuS. Kõks (Author/Creator) - University of TartuS. Haldre (Author/Creator) - University of Tartu
- Publication Details
- Epilepsia, Vol.56(11), pp.e172-e175
- Publisher
- Wiley Periodicals, Inc.
- Identifiers
- 991005540937707891
- Copyright
- © 2015 International League Against Epilepsy
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
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- Citation topics
- 1 Clinical & Life Sciences
- 1.222 Epilepsy & Seizures
- 1.222.143 Epilepsy Treatment
- Web Of Science research areas
- Clinical Neurology
- ESI research areas
- Neuroscience & Behavior