Vancomycin minimum inhibitory concentration, host comorbidities and mortality in Staphylococcus aureus bacteraemia

N.E. Holmes; J.D. Turnidge; W.J. Munckhof; J.O. Robinson; T.M. Korman; M.V.N. O'Sullivan; T.L. Anderson; S.A. Roberts; S.J.C. Warren; W. Gao; P.D.R. Johnson; B.P. Howden

doi:10.1111/1469-0691.12168

Back

Vancomycin minimum inhibitory concentration, host comorbidities and mortality in Staphylococcus aureus bacteraemia

Journal article

Open access

Peer reviewed

Vancomycin minimum inhibitory concentration, host comorbidities and mortality in Staphylococcus aureus bacteraemia

N.E. Holmes, J.D. Turnidge, W.J. Munckhof, J.O. Robinson, T.M. Korman, M.V.N. O'Sullivan, T.L. Anderson, S.A. Roberts, S.J.C. Warren, W. Gao, …

Clinical Microbiology and Infection, Vol.19(12), pp.1163-1168

2013

DOI: https://doi.org/10.1111/1469-0691.12168

Files and links (2)

pdf

Staphylococcus aureus bacteraemia.pdfDownload View

Published (Version of Record) Open Access

url

Free to Read *No subscription requiredView

Abstract

We reported an association between elevated vancomycin MIC and 30-day mortality in patients with Staphylococcus aureus bacteraemia (SAB), including patients with methicillin-susceptible S. aureus (MSSA) treated with flucloxacillin. A detailed analysis of comorbidities and disease severity scores in the same cohort of patients was performed to ascertain if unknown clinical parameters may have influenced these results. The association between elevated vancomycin MIC and 30-day mortality in SAB remained significant (p 0.001) on multivariable logistic regression analysis even when accounting for clinical factors. In addition, the association persisted when restricting analysis to patients with MSSA bacteraemia treated with flucloxacillin. This suggests that elevated vancomycin MIC is associated with but not causally linked to an organism factor that is responsible for increased mortality.

Details

Title: Vancomycin minimum inhibitory concentration, host comorbidities and mortality in Staphylococcus aureus bacteraemia
Authors/Creators: N.E. Holmes (Author/Creator) - The University of Melbourne
J.D. Turnidge (Author/Creator) - The University of Adelaide
W.J. Munckhof (Author/Creator) - The University of Queensland
J.O. Robinson (Author/Creator) - Royal Perth Hospital
T.M. Korman (Author/Creator) - Monash University
M.V.N. O'Sullivan (Author/Creator) - Westmead Hospital
T.L. Anderson (Author/Creator) - Royal Hobart Hospital
S.A. Roberts (Author/Creator) - Auckland District Health Board
S.J.C. Warren (Author/Creator) - Royal Hobart Hospital
W. Gao (Author/Creator) - Austin Health
P.D.R. Johnson (Author/Creator) - The University of Melbourne
B.P. Howden (Author/Creator) - Austin Health
Publication Details: Clinical Microbiology and Infection, Vol.19(12), pp.1163-1168
Publisher: Elsevier
Identifiers: 991005540168007891
Copyright: © 2013 The Authors.
Murdoch Affiliation: Murdoch University
Language: English
Resource Type: Journal article

UN Sustainable Development Goals (SDGs)

This output has contributed to the advancement of the following goals:

Source: InCites

Metrics

6 File views/ downloads

81 Record Views

20 Times Cited - Web of Science

InCites Highlights

These are selected metrics from InCites Benchmarking & Analytics tool, related to this output

Collaboration types: Domestic collaboration; International collaboration
Citation topics: 1 Clinical & Life Sciences; 1.23 Antibiotics & Antimicrobials; 1.23.173 MRSA and VRE
Web Of Science research areas: Infectious Diseases; Microbiology
ESI research areas: Immunology