Journal article
Vanilloid-like agents: Potential therapeutic targeting of platelets?
Drug Development Research, Vol.74(7), pp.450-459
2013
Abstract
Capsaicinoids are the “hot” compounds present in placental tissues of Capsicum fruits that are responsible for capsicum's pungency. Capsaicinoids belong to the broader class of vanilloids that activate the nonselective cation channel, transient receptor potential vanilloid‐1 (TRPV1). Endogenous vanilloids include arachidonic acid derivatives that have different affinities for TRPV1 and are increasingly recognized as an important group of signaling molecules affecting tissue injury, pain, and inflammation. Furthermore, some endogenous vanilloids have high affinity for cannabinoid receptors (CB1 and CB2), which are present in platelets. The most well‐known and widely studied plant‐derived vanilloid, capsaicin, is reported to have antiplatelet properties, but the mechanism of action is uncertain. This article will briefly review the mechanisms involved in platelet activation and aggregation, discuss the properties of vanilloids and their receptor, TRPV1, and discuss whether the effects of vanilloids, and particularly capsaicinoids, on platelets may be exploited for therapeutic benefit.
Details
- Title
- Vanilloid-like agents: Potential therapeutic targeting of platelets?
- Authors/Creators
- M.J. Adams (Author/Creator)S.Y. Almaghrabi (Author/Creator)K.D.K. Ahuja (Author/Creator)D.P. Geraghty (Author/Creator)
- Publication Details
- Drug Development Research, Vol.74(7), pp.450-459
- Publisher
- Wiley
- Identifiers
- 991005544563707891
- Copyright
- © 2013 Wiley Periodicals, Inc.
- Murdoch Affiliation
- Murdoch University
- Language
- English
- Resource Type
- Journal article
UN Sustainable Development Goals (SDGs)
This output has contributed to the advancement of the following goals:
Source: InCites
Metrics
15 Record Views
InCites Highlights
These are selected metrics from InCites Benchmarking & Analytics tool, related to this output
- Citation topics
- 1 Clinical & Life Sciences
- 1.79 Molecular & Cell Biology - Physiology
- 1.79.1259 TRP Channel Functions
- Web Of Science research areas
- Chemistry, Medicinal
- Pharmacology & Pharmacy
- ESI research areas
- Pharmacology & Toxicology