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Verification of carrier status for Becker muscular dystrophy from analysis of a blighted ovum
Journal article   Peer reviewed

Verification of carrier status for Becker muscular dystrophy from analysis of a blighted ovum

S.D. Wilton, J. Goldblatt and N.G. Laing
Prenatal Diagnosis, Vol.13(8), pp.757-762
1993
DOI: https://doi.org/10.1002/pd.1970130810
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Abstract

The polymerase chain reaction (PCR) was used on material from a blighted ovum to confirm indirectly the carrier status of a woman with a family history of Becker muscular dystrophy. Conventional testing including creatine kinase levels, muscle biopsy, and EMG had been inconclusive, and on the basis of one elevated creatine kinase level, the woman had been designated a possible carrier. Ultrasound examination at 10 weeks of pregnancy indicated a blighted ovum, from which DNA was subsequently extracted and subjected to PCR testing for determination of sex and genotypic status with respect to the known familial deletion of the dystrophin gene. The blighted ovum was found to have a Y chromosome and also to be deleted for at least exon 6 of the dystrophin gene, indirectly indicating that the mother most likely carried the family mutation for Becker muscular dystrophy.

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Source: InCites

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Collaboration types
Domestic collaboration
Citation topics
1 Clinical & Life Sciences
1.255 Musculoskeletal Disorders
1.255.628 Duchenne Muscular Dystrophy
Web Of Science research areas
Genetics & Heredity
Obstetrics & Gynecology
ESI research areas
Clinical Medicine
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